<br>熊果酸的治疗潜力：与熊果酸的比较,Biomolecules

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熊果酸的治疗潜力：与熊果酸的比较
Biomolecules ( IF 4.8 ) Pub Date : 2020-11-02 , DOI: 10.3390/biom10111505
Juhyeon Son ₁ , Sang Yeol Lee ₁

Affiliation

几个世纪以来，植物一直被用作治疗人类疾病的药物。熊果酸 (UNA) 是一种从某些药材（如枣）中提取的天然五环三萜类化合物。由于 UNA 的药理作用和相关机制尚不清楚，因此在这项工作中，我们尝试介绍 UNA 的治疗潜力，并与众所周知的次生代谢物熊果酸 (ULA) 进行比较，以获得有益效果。 UNA 在 C-3 位有一个酮基，这可能为 UNA 和 ULA 之间的不同生物活性提供了关键差异。此前的几项研究表明，UNA 的药效与 ULA 相似或更强，UNA 显着降低各种类型癌细胞的存活和增殖。 UNA 有可能对引起多种热带疾病的寄生原生动物发挥抑制作用。 UNA 还发挥其他潜在作用，包括降血糖、抗炎、抗病毒和抗氧化活性。值得注意的是，最近的一项研究强调了 UNA 对严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 的抑制潜力。 UNA 的分子修饰可以提高生物利用度，这对于体内和临床研究至关重要。总之，UNA在抗癌和抗原虫药物方面具有广阔的开发潜力。深入研究可能会增加UNA被开发为新型化疗试剂的可能性。

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Therapeutic Potential of Ursonic Acid: Comparison with Ursolic Acid

Plants have been used as drugs to treat human disease for centuries. Ursonic acid (UNA) is a naturally occurring pentacyclic triterpenoid extracted from certain medicinal herbs such as Ziziphus jujuba. Since the pharmacological effects and associated mechanisms of UNA are not well-known, in this work, we attempt to introduce the therapeutic potential of UNA with a comparison to ursolic acid (ULA), a well-known secondary metabolite, for beneficial effects. UNA has a keto group at the C-3 position, which may provide a critical difference for the varied biological activities between UNA and ULA. Several studies previously showed that UNA exerts pharmaceutical effects similar to, or stronger than, ULA, with UNA significantly decreasing the survival and proliferation of various types of cancer cells. UNA has potential to exert inhibitory effects in parasitic protozoa that cause several tropical diseases. UNA also exerts other potential effects, including antihyperglycemic, anti-inflammatory, antiviral, and antioxidant activities. Of note, a recent study highlighted the suppressive potential of UNA against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Molecular modifications of UNA may enhance bioavailability, which is crucial for in vivo and clinical studies. In conclusion, UNA has promising potential to be developed in anticancer and antiprotozoan pharmaceuticals. In-depth investigations may increase the possibility of UNA being developed as a novel reagent for chemotherapy.

更新日期：2020-11-02

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