Engineering Biofunctional Enzyme‐Mimics for Catalytic Therapeutics and Diagnostics,Advanced Functional Materials

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Engineering Biofunctional Enzyme‐Mimics for Catalytic Therapeutics and Diagnostics
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2020-11-02 , DOI: 10.1002/adfm.202007475
Qing Tang ₁ , Sujiao Cao ₁ , Tian Ma ₁ , Xi Xiang ₁ , Hongrong Luo ₂ , Pavel Borovskikh ₃ , Raul D. Rodriguez ₄ , Quanyi Guo ₅ , Li Qiu ₁ , Chong Cheng _{1,

6}

Affiliation

The applications of nanomaterial‐based enzyme‐mimics (Enz‐Ms) in biocatalytically therapeutic and diagnostic fields have attracted extensive attention. The regulation of the biocatalytic performances and biofunctionalities of Enz‐Ms are essential research objectives, including the rational design and synthesis of Enz‐Ms with desired biofunctional molecules and nanostructures, especially at the level of molecules and even single atoms. Here, this timely progress report provides pivotal advances and comments on recent researches on engineering biofunctional Enz‐Ms (BF/Enz‐Ms), particularly chemical synthesis, functionalization strategies, and integration of diverse enzyme‐mimetic catalytic activities of BF/Enz‐Ms. First, the definitions and catalogs of BF/Enz‐Ms are briefly introduced. Then, detailed comments and discussions are provided on the fabrication protocols, biocatalytic properties, and therapeutic/diagnostic applications of engineered BF/Enz‐Ms via hydrogels, nanogels, metal–organic frameworks, metal–polyphenol networks, covalent–organic frameworks, functional cell membranes, bioactive molecules and polymers, and composites. Finally, the future perspectives and challenges on BF/Enz‐Ms are outlined and thoroughly discussed. It is believed that this progress report will give a chemical and material overview on the state‐of‐the‐art designing principles of BF/Enz‐Ms, thus further promoting their future developments and prosperities for a wide range of applications.

中文翻译：

工程生物功能酶模拟物，用于催化治疗和诊断

基于纳米材料的酶模拟物（Enz-Ms）在生物催化治疗和诊断领域的应用引起了广泛关注。Enz-Ms的生物催化性能和生物功能的调节是必不可少的研究目标，包括合理设计和合成具有所需生物功能分子和纳米结构的Enz-Ms，尤其是在分子甚至单个原子的水平上。在这里，这份及时的进度报告提供了重要的进展，并对工程生物功能性Enz-Ms（BF / Enz-Ms）的最新研究提供了评论，特别是化学合成，功能化策略以及BF / Enz-Ms的多种酶模拟催化活性的整合。首先，简要介绍了BF / Enz-M的定义和目录。然后，通过水凝胶，纳米凝胶，金属-有机骨架，金属-多酚网络，共价-有机骨架，功能细胞膜，生物活性分子和聚合物，以及复合材料。最后，概述并充分讨论了BF / Enz-Ms的未来前景和挑战。据信，该进展报告将对高炉/ Enz-Ms的最新设计原理进行化学和材料概述，从而进一步促进其在广泛应用中的未来发展和繁荣。金属-多酚网络，共价-有机框架，功能性细胞膜，生物活性分子和聚合物以及复合材料。最后，概述并充分讨论了BF / Enz-Ms的未来前景和挑战。据信，该进展报告将对高炉/ Enz-Ms的最新设计原理进行化学和材料概述，从而进一步促进其在广泛应用中的未来发展和繁荣。金属-多酚网络，共价-有机框架，功能性细胞膜，生物活性分子和聚合物以及复合材料。最后，概述并充分讨论了BF / Enz-Ms的未来前景和挑战。据信，该进展报告将对高炉/ Enz-Ms的最新设计原理进行化学和材料概述，从而进一步促进其在广泛应用中的未来发展和繁荣。

更新日期：2020-11-02

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