当前位置: X-MOL 学术Biomed. Pharmacother. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Therapeutic promises of ginkgolide A: A literature-based review
Biomedicine & Pharmacotherapy ( IF 6.9 ) Pub Date : 2020-11-01 , DOI: 10.1016/j.biopha.2020.110908
Chandan Sarkar , Cristina Quispe , Sarmin Jamaddar , Rajib Hossain , Pranta Ray , Milon Mondal , Zeinab Abdulwanis Mohamed , Mohammed Sani Jaafaru , Bahare Salehi , Muhammad Torequl Islam , Ahmad Faizal Abdull Razis , Miquel Martorell , Edgar Pastene-Navarrete , Javad Sharifi-Rad

Ginkgolide A is a highly active platelet activating factor antagonist cage molecule which was isolated from the leaves of the Ginkgo biloba L. It is known for its inflammatory and immunological potentials. This review aims to sketch a current scenario on its therapeutic activities on the basis of scientific reports in the databases. A total 30 articles included in this review suggests that ginkgolide A has many important biological activities, including anti-inflammatory, anticancer, anxiolytic-like, anti-atherosclerosis and anti-atherombosis, neuro- and hepatoprotective effects. There is a lack of its toxicological (e.g. toxicity, cytotoxicity, genotoxicity and mutagenitcity) profile. In conclusion, ginkgolide A may be one of the potential therapeutic lead compounds, especially for the treatment of cardiovascular, hepatological, and neurological diseases and disorders. More studies are necessary on this hopeful therapeutic agent.



中文翻译:

银杏内酯A的治疗前景:基于文献的综述

银杏内酯A是一种高活性的血小板活化因子拮抗剂笼分子,从银杏叶中分离出来。它具有炎性和免疫学潜能。这篇综述旨在根据数据库中的科学报告勾画出其治疗活动的最新情况。该评价总共包括30篇文章,表明银杏内酯A具有许多重要的生物学活性,包括抗炎,抗癌,抗焦虑药,抗动脉粥样硬化和抗动脉粥样硬化,神经和肝保护作用。缺乏其毒理学(例如毒性,细胞毒性,遗传毒性和诱变性)。总之,银杏内酯A可能是潜在的治疗性先导化合物之一,尤其是用于治疗心血管,肝脏和神经疾病和病症。这种有希望的治疗剂需要更多的研究。

更新日期:2020-11-02
down
wechat
bug