在患慢性牙龈口炎的猫中，全口拔牙前的干细胞治疗缺乏实质性的临床疗效,Journal of Feline Medicine and Surgery

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在患慢性牙龈口炎的猫中，全口拔牙前的干细胞治疗缺乏实质性的临床疗效
Journal of Feline Medicine and Surgery ( IF 1.9 ) Pub Date : 2020-10-29 , DOI: 10.1177/1098612x20967172
Boaz Arzi _{1,

2} , Nopmanee Taechangam _{2,

3} , Milinda J Lommer _{1,

4} , Naomi J Walker _{2,

3} , Megan R Loscar ₅ , Dori L Borjesson _{2,

3}

Affiliation

目的本初步研究的目的是确定在全口拔牙前对患有猫慢性牙龈口炎 (FCGS) 的猫全身施用脂肪源性间充质干细胞 (ASC) 的安全性、有效性和免疫调节功能。方法五只客户拥有的患有 FCGS 的猫没有接受全口拔牙进行 FCGS 治疗，接受了两次静脉注射 2000 万个新鲜的、同种异体的或自体的 ASC。在治疗后 0 个月和 6 个月完成口腔检查，包括照片、全血细胞计数、血液免疫细胞表型和生化特征。结果四只猫完成了研究，一只猫在治疗后 3 个月退出了研究。虽然该治疗被确定为临床安全的，在三只猫中没有观察到阳性的临床反应，在两只猫中观察到轻微的反应。此外，没有一只猫表现出免疫调节，这可以通过循环 CD8+ T 细胞的变化、CD4:CD8 比率或中性粒细胞计数正常化来证明。结论和相关性与报道的 ASCs 治疗全口拔牙后无反应性 FCGS 猫的疗效不同，在全口拔牙前全身给药 ASCs 缺乏实质性的临床疗效，此时不推荐。

"点击查看英文标题和摘要"

Stem cell therapy prior to full-mouth tooth extraction lacks substantial clinical efficacy in cats affected by chronic gingivostomatitis

OBJECTIVES The aim of this pilot study was to determine the safety, efficacy and immunomodulatory function of systemically administered adipose-derived mesenchymal stem cells (ASCs) in cats affected by feline chronic gingivostomatitis (FCGS) prior to full-mouth tooth extractions. METHODS Five client-owned cats affected with FCGS that did not undergo full-mouth tooth extractions for FCGS treatment received two intravenous injections of 20 million fresh, allogeneic or autologous ASCs. An oral examination with photographs, a complete blood count, blood immune cell phenotyping and a biochemical profile were completed at 0 and 6 months after treatment. RESULTS Four cats completed the study and one cat exited the study 3 months after treatment. While the treatment was determined to be clinically safe, no positive clinical response was observed in three cats and a mild response was noted in two cats. Furthermore, none of the cats exhibited immune modulation, as evidenced by no alteration in circulating CD8+ T cells, normalization of the CD4:CD8 ratio or neutrophil counts. CONCLUSIONS AND RELEVANCE Unlike the reported efficacy of ASCs in treating cats with non-responsive FCGS after full-mouth tooth extraction, the systemic administration of ASCs prior to full-mouth tooth extraction lacks substantial clinical efficacy and is not recommended at this time.

更新日期：2020-10-29

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