Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) is a rare benign rheumatological condition characterized by sudden-onset symmetrical distal extremity edema. It can present as an isolated disease process or could be associated with other conditions. Rheumatoid factor and anticitrullinated protein antibodies are negative by definition. In current literature, there is paucity of data about the disease process. We performed a literature search using the PubMed database to identify 38 articles that met our inclusion and exclusion criteria. Our literature review focuses on the clinical picture and its diverse associations. Role of various acute phase reactants has also been outlined. There is a generalized consensus among clinicians on using moderate dose steroids for treatment. Other management options for refractory cases have also discussed. Value of several imaging modalities in diagnostic evaluation of this disease entity is touched on. Since RS3PE can be associated with other diseases, specifically cancer, timely diagnosis of this condition is necessary.

中文翻译：

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缓解伴有凹陷性水肿的血清阴性对称性滑膜炎：综述

缓解性血清阴性对称性滑膜炎伴凹陷性水肿 (RS3PE) 是一种罕见的良性风湿病，其特征是突然发作的对称性肢体远端水肿。它可以表现为一个孤立的疾病过程或可能与其他条件有关。根据定义，类风湿因子和抗瓜氨酸蛋白抗体是阴性的。在目前的文献中，关于疾病过程的数据很少。我们使用 PubMed 数据库进行了文献搜索，以确定符合我们纳入和排除标准的 38 篇文章。我们的文献综述侧重于临床表现及其各种关联。还概述了各种急性期反应物的作用。临床医生对使用中等剂量的类固醇进行治疗已达成普遍共识。还讨论了难治性病例的其他管理选择。涉及几种成像方式在该疾病实体的诊断评估中的价值。由于 RS3PE 可能与其他疾病有关，特别是癌症，因此必须及时诊断这种情况。