CO2‐Controlled Reductive Amination Reactions with NaBH4,European Journal of Organic Chemistry

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CO2‐Controlled Reductive Amination Reactions with NaBH4
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2020-10-30 , DOI: 10.1002/ejoc.202001408
Allan R. Petersen ₁ , Jerik Mathew Valera Lauridsen ₁ , Ji‐Woong Lee ₁

Affiliation

The reactivity of NaBH₄ was controlled by atmospheric CO₂, thus suppressing direct reduction of aldehydes to alcohols. High selectivities towards reductive amination alkylation reactions indicate the in‐situ formation of less reducing NaBH(OCHO)₃. This protocol provides a surrogate for conventional reducing reagents in reductive amination reactions.