Metal–Organic‐Framework‐Engineered Enzyme‐Mimetic Catalysts,Advanced Materials

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Metal–Organic‐Framework‐Engineered Enzyme‐Mimetic Catalysts
Advanced Materials ( IF 27.4 ) Pub Date : 2020-10-30 , DOI: 10.1002/adma.202003065
Lang Ma ₁ , Fuben Jiang ₁ , Xin Fan ₂ , Liyun Wang ₁ , Chao He ₁ , Mi Zhou ₃ , Shuang Li ₄ , Hongrong Luo ₅ , Chong Cheng _{1,

2} , Li Qiu ₁

Affiliation

Nanomaterial‐based enzyme‐mimetic catalysts (Enz‐Cats) have received considerable attention because of their optimized and enhanced catalytic performances and selectivities in diverse physiological environments compared with natural enzymes. Recently, owing to their molecular/atomic‐level catalytic centers, high porosity, large surface area, high loading capacity, and homogeneous structure, metal–organic frameworks (MOFs) have emerged as one of the most promising materials in engineering Enz‐Cats. Here, the recent advances in the design of MOF‐engineered Enz‐Cats, including their preparation methods, composite constructions, structural characterizations, and biomedical applications, are highlighted and commented upon. In particular, the performance, selectivities, essential mechanisms, and potential structure–property relations of these MOF‐engineered Enz‐Cats in accelerating catalytic reactions are discussed. Some potential biomedical applications of these MOF‐engineered Enz‐Cats are also breifly proposed. These applications include, for example, tumor therapies, bacterial disinfection, tissue regeneration, and biosensors. Finally, the future opportunities and challenges in emerging research frontiers are thoroughly discussed. Thereby, potential pathways and perspectives for designing future state‐of‐the‐art Enz‐Cats in biomedical sciences are offered.

中文翻译：

金属有机骨架工程酶模拟催化剂

与天然酶相比，基于纳米材料的酶模拟催化剂（Enz-Cats）因其在不同生理环境中优化和增强的催化性能和选择性而受到广泛关注。近年来，由于其分子/原子级催化中心、高孔隙率、大表面积、高负载能力和均质结构，金属有机框架（MOF）已成为工程Enz-Cats中最有前途的材料之一。在此，重点介绍并评论了 MOF 工程 Enz-Cats 设计的最新进展，包括其制备方法、复合结构、结构表征和生物医学应用。特别是，讨论了这些 MOF 工程的 Enz-Cats 在加速催化反应中的性能、选择性、基本机制和潜在的结构-性能关系。还简要提出了这些 MOF 工程 Enz-Cats 的一些潜在生物医学应用。这些应用包括肿瘤治疗、细菌消毒、组织再生和生物传感器等。最后，深入讨论了新兴研究领域的未来机遇和挑战。因此，为生物医学领域设计未来最先进的 Enz-Cats 提供了潜在的途径和前景。

更新日期：2020-12-08

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