Nature‐Inspired Construction of MOF@COF Nanozyme with Active Sites in Tailored Microenvironment and Pseudopodia‐Like Surface for Enhanced Bacterial Inhibition,Angewandte Chemie International Edition

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Nature‐Inspired Construction of MOF@COF Nanozyme with Active Sites in Tailored Microenvironment and Pseudopodia‐Like Surface for Enhanced Bacterial Inhibition
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2020-10-28 , DOI: 10.1002/anie.202012487
Lu Zhang _{1,

2} , Zhengwei Liu _{1,

2} , Qingqing Deng _{1,

3} , Yanjuan Sang _{1,

3} , Kai Dong ₁ , Jinsong Ren _{1,

2,

3} , Xiaogang Qu _{1,

2,

3}

Affiliation

Metal–organic frameworks (MOFs) have sparked increasing interest in mimicking the structure and function of natural enzymes. However, their catalytic and therapeutic efficiency are unsatisfactory due to the relatively lower catalytic activity. Herein, inspired by nature, a MOF@COF nanozyme has been designed as a high‐efficiency peroxidase mimic, with the metallic nodes of MOFs as active centres, the hierarchical nanocavities produced by the growth of covalent organic frameworks (COFs) as binding pockets to form tailored pore microenvironment around active sites for enriching and activating substrate molecules, to perform enhanced bacterial inhibition. Furthermore, the pseudopodia‐like surface of the COFs “skin” enabled the system to catch the bacteria effectively for further amplifying the therapeutic efficiency of MOF‐based nanozyme. We believe that the present study will not only facilitate the design of novel nanozymes, but also broaden the biological usage of MOF/COF‐based hybrid materials.

中文翻译：

以自然为灵感的MOF @ COF纳米酶的构建，在定制的微环境和伪足样表面具有活性位点，可增强细菌抑制作用

金属有机框架（MOF）引发了人们对模仿天然酶的结构和功能的兴趣。然而，由于相对较低的催化活性，它们的催化和治疗效率不能令人满意。在这里，受自然界的启发，MOF @ COF纳米酶被设计为一种高效的过氧化物酶模拟物，以MOF的金属节点为活性中心，由共价有机骨架（COF）的生长产生的层级纳米腔作为结合口袋。在活性位点周围形成定制的孔微环境，以富集和激活底物分子，以增强细菌抑制作用。此外，COF“皮肤”的伪足样表面使系统能够有效捕获细菌，从而进一步提高基于MOF的纳米酶的治疗效率。

更新日期：2020-10-28

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