Conformationally Constrained Glycosyl Donors as Tools to Control Glycosylation Outcomes,The Journal of Organic Chemistry

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Conformationally Constrained Glycosyl Donors as Tools to Control Glycosylation Outcomes
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2020-10-26 , DOI: 10.1021/acs.joc.0c02045
Robin A Jeanneret ₁ , Simon E Johnson ₁ , M Carmen Galan ₁

Affiliation

The stereoselective synthesis of oligosaccharides remains one of the biggest challenges in carbohydrate chemistry. Many factors, including reaction conditions and the type of glycosyl donor and acceptor used, can affect the outcome of glycosylation reactions. In this Perspective, we discuss methods aimed to control the reactivity and stereoselectivity of glycosylation reactions using conformationally constrained glycosyl donors, with a focus on more recently developed chemistry.

中文翻译：

构象约束糖基供体作为控制糖基化结果的工具

寡糖的立体选择性合成仍然是碳水化合物化学中最大的挑战之一。许多因素，包括反应条件和所用糖基供体和受体的类型，都会影响糖基化反应的结果。在这个观点中，我们讨论了旨在使用构象受限的糖基供体控制糖基化反应的反应性和立体选择性的方法，重点是最近开发的化学。

更新日期：2020-12-18

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