针对细菌致病因子的植物天然产物,Chemical Reviews

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针对细菌致病因子的植物天然产物
Chemical Reviews ( IF 51.4 ) Pub Date : 2016-07-20 00:00:00 , DOI: 10.1021/acs.chemrev.6b00184
Laura Nunes Silva _{1,

2} , Karine Rigon Zimmer ₃ , Alexandre José Macedo _{1,

2,

4} , Danielle Silva Trentin _{1,

2}

Affiliation

抗菌效率下降已成为全球公共卫生问题。新抗菌药物的匮乏是显而易见的，应对传染病的武器库亟待改进。选择植物作为原型化合物的来源是适当的，因为植物物种自然会产生广泛的次级代谢产物，这些代谢产物可作为抵抗环境中微生物的化学防线。尽管对抗微生物感染的传统方法仍然有效，但针对微生物的毒力而不是生存似乎是一个令人兴奋的策略，因为对毒力因子的调节可能会导致耐药性发展的温和进化压力。此外，抗感染化学疗法可通过将抗毒剂和常规抗微生物剂联合使用来成功实现，延长这些药物的寿命。这篇综述介绍了从植物中分离出的天然化合物的最新讨论，这些化合物具有化学特征的结构和针对主要细菌毒力因子的活性：群体感应，细菌生物膜，细菌运动性，细菌毒素，细菌色素，细菌酶和细菌表面活性剂。此外，对最有希望的毒力因子进行了批判性分析，强调了它们作为减弱细菌毒力的靶标的潜力。因此，抗病毒治疗领域的不断进步可能有助于将这一有前途的概念转化为临床领域的实际干预策略。这篇综述介绍了从植物中分离出的天然化合物的最新讨论，这些化合物具有化学特征的结构和针对主要细菌毒力因子的活性：群体感应，细菌生物膜，细菌运动性，细菌毒素，细菌色素，细菌酶和细菌表面活性剂。此外，对最有希望的毒力因子进行了批判性分析，强调了它们作为减弱细菌毒力的靶标的潜力。因此，抗病毒治疗领域的不断进步可能有助于将这一有前途的概念转化为临床领域的实际干预策略。这篇综述介绍了从植物中分离出的天然化合物的最新讨论，这些化合物具有化学特征的结构和针对主要细菌毒力因子的活性：群体感应，细菌生物膜，细菌运动性，细菌毒素，细菌色素，细菌酶和细菌表面活性剂。此外，对最有希望的毒力因子进行了批判性分析，强调了它们作为减弱细菌毒力的靶标的潜力。因此，抗病毒治疗领域的不断进步可能有助于将这一有前途的概念转化为临床领域的实际干预策略。提出了对最有希望的毒力因子的关键分析，强调了它们作为减毒细菌毒力的靶标的潜力。因此，抗病毒治疗领域的不断进步可能有助于将这一有前途的概念转化为临床领域的实际干预策略。提出了对最有希望的毒力因子的关键分析，强调了它们作为减毒细菌毒力的靶标的潜力。因此，抗病毒治疗领域的不断进步可能有助于将这一有前途的概念转化为临床领域的实际干预策略。

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Plant Natural Products Targeting Bacterial Virulence Factors

Decreased antimicrobial efficiency has become a global public health issue. The paucity of new antibacterial drugs is evident, and the arsenal against infectious diseases needs to be improved urgently. The selection of plants as a source of prototype compounds is appropriate, since plant species naturally produce a wide range of secondary metabolites that act as a chemical line of defense against microorganisms in the environment. Although traditional approaches to combat microbial infections remain effective, targeting microbial virulence rather than survival seems to be an exciting strategy, since the modulation of virulence factors might lead to a milder evolutionary pressure for the development of resistance. Additionally, anti-infective chemotherapies may be successfully achieved by combining antivirulence and conventional antimicrobials, extending the lifespan of these drugs. This review presents an updated discussion of natural compounds isolated from plants with chemically characterized structures and activity against the major bacterial virulence factors: quorum sensing, bacterial biofilms, bacterial motility, bacterial toxins, bacterial pigments, bacterial enzymes, and bacterial surfactants. Moreover, a critical analysis of the most promising virulence factors is presented, highlighting their potential as targets to attenuate bacterial virulence. The ongoing progress in the field of antivirulence therapy may therefore help to translate this promising concept into real intervention strategies in clinical areas.

更新日期：2016-07-20

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