Chirality Detection by Raman Spectroscopy: The Case of Enantioselective Interactions between Amino Acids and Polymer-Modified Chiral Silica,Analytical Chemistry

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Chirality Detection by Raman Spectroscopy: The Case of Enantioselective Interactions between Amino Acids and Polymer-Modified Chiral Silica
Analytical Chemistry ( IF 6.7 ) Pub Date : 2020-10-21 , DOI: 10.1021/acs.analchem.0c03286
Huanjun Kong ₁ , Xueping Sun ₁ , Liu Yang ₁ , Xinling Liu ₁ , Haifeng Yang ₁ , Ren-Hua Jin ₂

Affiliation

In chirality research area, it is of interest to reveal the chiral feature of inorganic nanomaterials and their enantioselective interactions with biomolecules. Although common Raman spectroscopy is not regarded as a direct chirality analysis tool, it is in fact effective and sensitive to study the enantioselectivity phenomena, which is demonstrated by the enantio-discrimination of amino acid enantiomers using the polydopamine-modified intrinsically chiral SiO₂ nanofibers in this work. The Raman scattering intensities of an enantiomer of cysteine are more than twice as high as those of the other enantiomer with opposite handedness. Similar results were also found in the cases of cystine, phenylalanine, and tryptophan enantiomers. In turn, these organic molecules could be used as chirality indicators for SiO₂, which was clarified by the unique Raman spectra-derived mirror-image relationships. Thus, an indirect chirality detection method for inorganic nanomaterials was developed.

中文翻译：

拉曼光谱手性检测：氨基酸和聚合物改性手性硅胶之间的对映选择性相互作用的情况。

在手性研究领域，有趣的是揭示无机纳米材料的手性特征及其与生物分子的对映选择性相互作用。尽管普通拉曼光谱法不被认为是直接的手性分析工具，但实际上它对研究对映选择性现象是有效和敏感的，这是通过使用聚多巴胺改性的本征手性SiO ₂纳米纤维对氨基酸对映异构体进行对映异构来证明的。这项工作。半胱氨酸对映异构体的拉曼散射强度比其他具有相反惯性的对映异构体的拉曼散射强度高两倍。在胱氨酸，苯丙氨酸和色氨酸对映异构体的情况下也发现了相似的结果。反过来，这些有机分子可用作SiO的手性指标_图2由独特的拉曼光谱派生的镜像关系阐明。因此，开发了一种用于无机纳米材料的间接手性检测方法。

更新日期：2020-11-03

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