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The Beneficial Effects of Apical Sodium‐Dependent Bile Acid Transporter Inactivation Depend on Dietary Fat Composition
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2020-10-20 , DOI: 10.1002/mnfr.202000750 Ivo P van de Peppel 1 , Anuradha Rao 2 , Marleen B Dommerholt 1 , Laura Bongiovanni 3 , Rachel Thomas 3 , Alain de Bruin 3 , Saul J Karpen 2 , Paul A Dawson 2 , Henkjan J Verkade 1 , Johan W Jonker 1
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2020-10-20 , DOI: 10.1002/mnfr.202000750 Ivo P van de Peppel 1 , Anuradha Rao 2 , Marleen B Dommerholt 1 , Laura Bongiovanni 3 , Rachel Thomas 3 , Alain de Bruin 3 , Saul J Karpen 2 , Paul A Dawson 2 , Henkjan J Verkade 1 , Johan W Jonker 1
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The apical sodium‐dependent bile acid transporter (ASBT, SLC10A2) is important in the enterohepatic cycling of bile acids and thereby in the intestinal absorption of lipids. ASBT inhibition has been shown to improve aspects of the metabolic syndrome, but the underlying mechanisms have remained unclear. Here, the effect of ASBT inhibition on the uptake of specific fatty acids and its consequences for diet‐induced obesity and non‐alcoholic fatty liver disease (NAFLD) are investigated.
中文翻译：
顶端钠依赖性胆汁酸转运蛋白失活的有益效果取决于膳食脂肪成分
顶端钠依赖性胆汁酸转运蛋白（ASBT， SLC10A2 ）在胆汁酸的肠肝循环以及脂质的肠道吸收中非常重要。 ASBT 抑制已被证明可以改善代谢综合征的各个方面，但其潜在机制仍不清楚。在此，研究了 ASBT 抑制对特定脂肪酸摄取的影响及其对饮食引起的肥胖和非酒精性脂肪肝 (NAFLD) 的影响。
更新日期：2020-12-17
中文翻译：
顶端钠依赖性胆汁酸转运蛋白失活的有益效果取决于膳食脂肪成分
顶端钠依赖性胆汁酸转运蛋白（ASBT， SLC10A2 ）在胆汁酸的肠肝循环以及脂质的肠道吸收中非常重要。 ASBT 抑制已被证明可以改善代谢综合征的各个方面，但其潜在机制仍不清楚。在此，研究了 ASBT 抑制对特定脂肪酸摄取的影响及其对饮食引起的肥胖和非酒精性脂肪肝 (NAFLD) 的影响。
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