Bioengineering tools for probing intracellular events in T lymphocytes,WIREs Mechanisms of Disease

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Bioengineering tools for probing intracellular events in T lymphocytes
WIREs Mechanisms of Disease ( IF 4.6 ) Pub Date : 2020-10-19 , DOI: 10.1002/wsbm.1510
Xinyuan Zhang ₁ , Chelsea F Mariano ₁ , Yuta Ando ₁ , Keyue Shen _{1,

2,

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Affiliation

T lymphocytes are the central coordinator and executor of many immune functions. The activation and function of T lymphocytes are mediated through the engagement of cell surface receptors and regulated by a myriad of intracellular signaling network. Bioengineering tools, including imaging modalities and fluorescent probes, have been developed and employed to elucidate the cellular events throughout the functional lifespan of T cells. A better understanding of these events can broaden our knowledge in the immune systems biology, as well as accelerate the development of effective diagnostics and immunotherapies. Here we review the commonly used and recently developed techniques and probes for monitoring T lymphocyte intracellular events, following the order of intracellular events in T cells from activation, signaling, metabolism to apoptosis. The techniques introduced here can be broadly applied to other immune cells and cell systems.

中文翻译：

用于探测 T 淋巴细胞细胞内事件的生物工程工具

T淋巴细胞是许多免疫功能的中心协调者和执行者。T淋巴细胞的激活和功能是通过细胞表面受体的参与介导的，并受无数细胞内信号网络的调节。生物工程工具，包括成像方式和荧光探针，已被开发并用于阐明 T 细胞整个功能寿命期间的细胞事件。更好地了解这些事件可以拓宽我们在免疫系统生物学方面的知识，并加速有效诊断和免疫疗法的发展。在这里，我们回顾了常用和最近开发的用于监测 T 淋巴细胞细胞内事件的技术和探针，按照 T 细胞中的细胞内事件从激活、信号传导、代谢到细胞凋亡的顺序进行。

更新日期：2020-10-19

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