The regeneration of tissues and organs poses an immense challenge due to the extreme complexity in the research work involved. Despite the tissue engineering approach being considered as a promising strategy for more than two decades, a key issue impeding its progress is the lack of ideal scaffold materials. Nature-inspired synthetic peptide hydrogels are inherently biocompatible, and its high resemblance to extracellular matrix makes peptide hydrogels suitable 3D scaffold materials. This review covers the important aspects of peptide hydrogels as 3D scaffolds, including mechanical properties, biodegradability and bioactivity, and the current approaches in creating matrices with optimized features. Many of these scaffolds contain peptide sequences that are widely reported for tissue repair and regeneration and these peptide sequences will also be discussed. Furthermore, 3D biofabrication strategies of synthetic peptide hydrogels and the recent advances of peptide hydrogels in tissue engineering will also be described to reflect the current trend in the field. In the final section, we will present the future outlook in the design and development of peptide-based hydrogels for translational tissue engineering applications.

由于所涉及的研究工作极其复杂，组织和器官的再生构成了巨大的挑战。尽管组织工程方法被认为是一种有前途的策略，但阻碍其进展的一个关键问题是缺乏理想的支架材料。受自然启发的合成肽水凝胶具有固有的生物相容性，其与细胞外基质的高度相似性使肽水凝胶成为合适的 3D 支架材料。这篇综述涵盖了肽水凝胶作为 3D 支架的重要方面，包括机械性能、生物降解性和生物活性，以及​​当前创建具有优化特征的矩阵的方法。许多这些支架包含广泛报道用于组织修复和再生的肽序列，这些肽序列也将被讨论。此外，还将描述合成肽水凝胶的 3D 生物制造策略和肽水凝胶在组织工程中的最新进展，以反映该领域的当前趋势。在最后一部分，我们将介绍用于翻译组织工程应用的基于肽的水凝胶的设计和开发的未来前景。