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Rhodium-Catalyzed Oxidative Olefination of N-(2-(4,5-Dihydrooxazol-2-yl)phenyl)amides with Arylethenes via Extraordinary N-Aryl C-H Bond Functionalization
Heterocycles ( IF 0.8 ) Pub Date : 2020-10-16 , DOI: 10.3987/com-20-14346
Hao Yan , Guosheng Huang , Fang-Peng Hu , Xiao-Qiang Zhou , Zhi Li

Amide-tethered aryloxazoline motifs are important structural moiety because of ubiquity in medicinal chemistry, functional materials and pincer ligands. In recent years, much attention about N-(2-(4,5-dihydrooxazol-2-yl)phenyl)amides has been focused on ortho C−H functionalization of amides. Herein a highly efficient rhodium(III) catalyzed oxidative olefination of N-(2-(4,5-dihydrooxazol-2-yl)phenyl)amides with arylethenes via extraordinary N-aryl C-H bond functionalization was developed.

中文翻译:

铑催化的N-(2-(4,5-二氢恶唑-2-基)苯基)酰胺与丙烯酰胺的非常规N-芳基CH键官能化

由于在医学化学,功能材料和钳位配体中无处不在,因此,由酰胺束缚的芳基恶唑啉基序是重要的结构部分。近年来,对N-(2-(4,5-二氢恶唑-2-基)苯基)酰胺的关注已集中在酰胺的邻位CH官能化上。本文开发了N-(2-(4,5-二氢恶唑-2-基)苯基)酰胺与芳烃经非凡的N-芳基CH键官能化反应的高效铑(III)催化氧化烯化反应。
更新日期:2020-10-16
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