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Tumor Noninvasive and Target Embolization Therapy Platform by Intravenous Injection Based on Acidic Microenvironment-Responsive Hyperbranched Poly(amino acid)s
ACS Central Science ( IF 12.7 ) Pub Date : 2020-10-15 , DOI: 10.1021/acscentsci.0c00506 Dedai Lu 1 , Jiachen Wang 1 , Yunfei Li 1 , Yongyong Zhang 1 , Lili Yu 1 , Tingting Xu 2 , Hongyun Guo 3 , Yongdong Zhang 3 , Xingdong Wang 3 , Xiaoqi Wang 3 , Gaojun Teng 2 , Ziqiang Lei 1
ACS Central Science ( IF 12.7 ) Pub Date : 2020-10-15 , DOI: 10.1021/acscentsci.0c00506 Dedai Lu 1 , Jiachen Wang 1 , Yunfei Li 1 , Yongyong Zhang 1 , Lili Yu 1 , Tingting Xu 2 , Hongyun Guo 3 , Yongdong Zhang 3 , Xingdong Wang 3 , Xiaoqi Wang 3 , Gaojun Teng 2 , Ziqiang Lei 1
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Transcatheter arterial embolization (TAE) has been widely applied in treatments of unresectable or hypervascular tumors, but the procedure of TAE is complicated possibly brings inherent risks. Here, inspired by pH-responsive drug delivery systems, a new method of noninvasive and target embolization therapy by intravenous injection was developed. This method is based on a type of acidic microenvironment-responsive hyperbranched poly(amino acid) (HPTTG) to avoid using catheterization and real-time image guidance angiography, simplifying the procedure, elevating compliance and general applicability of embolization therapy. The pH value of the sol-to-gel phase transition with decreasing pH of HPTTG was controlled by adjusting the ratio of acidic amino acids in copolymers. The results of the tumor-bearing animal experiment indicate that the HPTTG have an excellent target and embolic ability; they accumulate the most at the tumor site in 8 h postinjection. Blood vessels of the tumors were occluded, and the tumors were inhibited and necrotized in about 20 days. Therefore, it is expected that HPTTG not only can be used as novel embolic materials for efficient noninvasive embolization therapy of many solid tumors but also can be used as a multifunctional platform for combined theranostics, for example, combination with controlled release, thermal ablation, multimodal imaging, synergistic therapy, etc.
中文翻译：
基于酸性微环境响应性超支化聚氨基酸的肿瘤静脉注射无创靶向栓塞治疗平台
经导管动脉栓塞（TAE）已广泛应用于不可切除或富血管肿瘤的治疗，但TAE操作复杂，可能带来固有的风险。在这里，受 pH 响应药物输送系统的启发，开发了一种通过静脉注射进行无创、靶向栓塞治疗的新方法。该方法基于一种酸性微环境响应性超支化聚氨基酸（HPTTG），避免了导管插入和实时图像引导血管造影，简化了手术过程，提高了栓塞治疗的依从性和普遍适用性。随着 HPTTG pH 值的降低，溶胶到凝胶相变的 pH 值是通过调节共聚物中酸性氨基酸的比例来控制的。荷瘤动物实验结果表明HPTTG具有良好的靶向性和栓塞能力；它们在注射后8小时内在肿瘤部位积聚最多。闭塞肿瘤血管，20天左右肿瘤被抑制坏死。因此，预计HPTTG不仅可以作为新型栓塞材料，用于多种实体瘤的高效无创栓塞治疗，而且可以作为组合治疗诊断的多功能平台，例如与控释、热消融、多模态组合等。影像学、协同治疗等
更新日期：2020-11-25
中文翻译：
基于酸性微环境响应性超支化聚氨基酸的肿瘤静脉注射无创靶向栓塞治疗平台
经导管动脉栓塞（TAE）已广泛应用于不可切除或富血管肿瘤的治疗，但TAE操作复杂，可能带来固有的风险。在这里，受 pH 响应药物输送系统的启发，开发了一种通过静脉注射进行无创、靶向栓塞治疗的新方法。该方法基于一种酸性微环境响应性超支化聚氨基酸（HPTTG），避免了导管插入和实时图像引导血管造影，简化了手术过程，提高了栓塞治疗的依从性和普遍适用性。随着 HPTTG pH 值的降低，溶胶到凝胶相变的 pH 值是通过调节共聚物中酸性氨基酸的比例来控制的。荷瘤动物实验结果表明HPTTG具有良好的靶向性和栓塞能力；它们在注射后8小时内在肿瘤部位积聚最多。闭塞肿瘤血管，20天左右肿瘤被抑制坏死。因此，预计HPTTG不仅可以作为新型栓塞材料，用于多种实体瘤的高效无创栓塞治疗，而且可以作为组合治疗诊断的多功能平台，例如与控释、热消融、多模态组合等。影像学、协同治疗等
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