Polysaccharide–Peptide Conjugates: A Versatile Material Platform for Biomedical Applications,Advanced Functional Materials

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Polysaccharide–Peptide Conjugates: A Versatile Material Platform for Biomedical Applications
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2020-10-14 , DOI: 10.1002/adfm.202005978
Hai‐Qing Song _{1,

2,

3} , Yaqian Fan ₂ , Yang Hu ₂ , Gang Cheng ₃ , Fu‐Jian Xu _{1,

2}

Affiliation

Natural polymers, such as polysaccharides and proteins, have been widely studied for numerous biomedical applications because of their bioactivity, natural origin, and biodegradability. To address the different needs of a broad spectrum of biomedical applications, natural polymers are modified with or conjugated to small molecular compounds, synthetic and natural polymers, and inorganic nanomaterials and surfaces. Among these hybrid materials, polysaccharide–peptide conjugates have drawn much attention due to their design flexibility, biocompatibility, tunable degradability, and structure similarity to naturally occurring glycoproteins. In the past 20 years, polysaccharide–peptide conjugates have demonstrated the promising potential to address many long‐standing medical challenges. Thus, the design, conjugation chemistry and method, and biomedical applications of polysaccharide–peptide conjugates are summarized and discussed in this review. The conjugation techniques are reviewed from the view of the chemical reactions. Meanwhile, some inspiring examples of polysaccharide–peptide conjugates in biomedical applications, including drug delivery systems, nucleic acid delivery carriers, tissue engineering, and antimicrobial applications, are highlighted. Moreover, the outlook on the challenges and demands of polysaccharide–peptide conjugates is also elaborated.

中文翻译：

多糖-肽结合物：生物医学应用的多功能材料平台

天然聚合物，如多糖和蛋白质，由于其生物活性，天然来源和可生物降解性，已被广泛研究用于许多生物医学应用。为了满足广泛的生物医学应用的不同需求，天然聚合物被改性或与小分子化合物，合成和天然聚合物以及无机纳米材料和表面共轭。在这些杂合材料中，多糖-肽共轭物因其设计灵活性，生物相容性，可调降解性和与天然糖蛋白的结构相似性而备受关注。在过去的20年中，多糖肽共轭物已显示出解决许多长期医学难题的潜力。因此，设计，结合化学和方法这篇综述总结并讨论了多糖-肽结合物的生物医学应用。从化学反应的观点综述了缀合技术。同时，重点介绍了在生物医学应用中令人鼓舞的多糖多肽结合物的一些实例，包括药物输送系统，核酸输送载体，组织工程和抗菌应用。此外，还阐述了多糖-肽共轭物的挑战和需求的前景。重点介绍了核酸传递载体，组织工程和抗菌应用。此外，还阐述了多糖-肽共轭物的挑战和需求的前景。着重介绍了核酸传递载体，组织工程学和抗菌应用。此外，还阐述了多糖-肽共轭物的挑战和需求的前景。

更新日期：2020-10-14

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