<br>水飞蓟的健康益处：植物化学、药理学和应用,Journal of Agricultural and Food Chemistry

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水飞蓟的健康益处：植物化学、药理学和应用
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2020-10-12 , DOI: 10.1021/acs.jafc.0c04791
Xin Wang ₁ , Zhen Zhang ₁ , Shuai-Cheng Wu _{1,

2}

Affiliation

水飞蓟（SM）是一种著名的药食两用植物，已广泛用于治疗多种疾病，特别是肝脏疾病。 SM的种子和果实中含有黄酮木脂素复合物，称为水飞蓟素，其活性化合物包括水飞蓟宾、异水飞蓟宾、水飞蓟亭、二氢水飞蓟宾、水飞蓟宁等。在这篇综述中，我们全面总结了与 SM 药理作用和潜在机制相关的高质量出版物。 SM具有抗菌、抗癌、保肝、心血管、神经保护、皮肤保护、抗糖尿病等功效。重要的是，SM 还可以抵消抗生素、金属和农药的毒性。 SM 的多种药理活性提供了支持其在人类和动物中使用的科学证据。与氧化应激和炎症相关的多种信号通路是 SM 的常见分子靶点。此外，SM 的黄酮木脂素是 PPARγ 和 ABCA1 的潜在激动剂、PTP1B 抑制剂和金属螯合剂。综述的最后讨论了SM的潜力和前景，这些见解有望促进SM的应用以及新药的发现和开发。我们的结论是，SM 是一种有趣的膳食药物，可用于增强健康和药物发现，值得进一步研究。

"点击查看英文标题和摘要"

Health Benefits of Silybum marianum: Phytochemistry, Pharmacology, and Applications

Silybum marianum (SM), a well-known plant used as both a medicine and a food, has been widely used to treat various diseases, especially hepatic diseases. The seeds and fruits of SM contain a flavonolignan complex called silymarin, the active compounds of which include silybin, isosilybin, silychristin, dihydrosilybin, silydianin, and so on. In this review, we thoroughly summarize high-quality publications related to the pharmacological effects and underlying mechanisms of SM. SM has antimicrobial, anticancer, hepatoprotective, cardiovascular-protective, neuroprotective, skin-protective, antidiabetic, and other effects. Importantly, SM also counteracts the toxicities of antibiotics, metals, and pesticides. The diverse pharmacological activities of SM provide scientific evidence supporting its use in both humans and animals. Multiple signaling pathways associated with oxidative stress and inflammation are the common molecular targets of SM. Moreover, the flavonolignans of SM are potential agonists of PPARγ and ABCA1, PTP1B inhibitors, and metal chelators. At the end of the review, the potential and perspectives of SM are discussed, and these insights are expected to facilitate the application of SM and the discovery and development of new drugs. We conclude that SM is an interesting dietary medicine for health enhancement and drug discovery and warrants further investigation.

更新日期：2020-10-21

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