骨再生的生物材料的骨传导和骨诱导表面修饰：简要审查。,Coatings

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骨再生的生物材料的骨传导和骨诱导表面修饰：简要审查。
Coatings ( IF 2.9 ) Pub Date : 2020-10-12 , DOI: 10.3390/coatings10100971
Paulina Kazimierczak ₁ , Agata Przekora ₁

Affiliation

骨组织工程的主要目的是制造用于组织再生的高度生物相容性，骨传导性和/或骨诱导性生物材料。骨植入物应通过促进成骨细胞粘附，增殖和形成骨细胞外基质来支持植入部位的骨生长。此外，用于临床应用的生物材料非常期望的特征是它们的骨诱导能力，这意味着该材料诱导间充质干细胞向成骨细胞（成骨细胞）的成骨分化的能力。然而，具有适当的理化和机械性能的完全生物相容性生物材料的开发对研究人员提出了巨大的挑战。从而，生物材料工程的当前趋势集中在表面修饰上，以改善骨植入物的生物学特性。这篇综述提出了有关生物材料表面改性以改善其骨传导性和骨诱导性的最新发现。本文介绍了两种类型的表面修饰：（1）加性和（2）减性，表明所得表面在体外和/或体内的生物学作用。该综述文章总结了已知的添加剂改性方法，例如等离子处理，磁控溅射以及在植入物上制备无机，有机和复合涂层。它还介绍了一些用于生物材料表面改性的常用减法工艺（例如，酸蚀，喷砂，喷砂，喷砂大砂酸蚀（SLA），阳极氧化和激光方法）。总而言之，该文章是有关用于骨再生的生物材料上先进的骨传导性和/或骨诱导性涂层的表面改性和发展的极佳纲要。

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Osteoconductive and Osteoinductive Surface Modifications of Biomaterials for Bone Regeneration: A Concise Review

The main aim of bone tissue engineering is to fabricate highly biocompatible, osteoconductive and/or osteoinductive biomaterials for tissue regeneration. Bone implants should support bone growth at the implantation site via promotion of osteoblast adhesion, proliferation, and formation of bone extracellular matrix. Moreover, a very desired feature of biomaterials for clinical applications is their osteoinductivity, which means the ability of the material to induce osteogenic differentiation of mesenchymal stem cells toward bone-building cells (osteoblasts). Nevertheless, the development of completely biocompatible biomaterials with appropriate physicochemical and mechanical properties poses a great challenge for the researchers. Thus, the current trend in the engineering of biomaterials focuses on the surface modifications to improve biological properties of bone implants. This review presents the most recent findings concerning surface modifications of biomaterials to improve their osteoconductivity and osteoinductivity. The article describes two types of surface modifications: (1) Additive and (2) subtractive, indicating biological effects of the resultant surfaces in vitro and/or in vivo. The review article summarizes known additive modifications, such as plasma treatment, magnetron sputtering, and preparation of inorganic, organic, and composite coatings on the implants. It also presents some common subtractive processes applied for surface modifications of the biomaterials (i.e., acid etching, sand blasting, grit blasting, sand-blasted large-grit acid etched (SLA), anodizing, and laser methods). In summary, the article is an excellent compendium on the surface modifications and development of advanced osteoconductive and/or osteoinductive coatings on biomaterials for bone regeneration.

更新日期：2020-10-12

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