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The development of an antifouling interpenetrating polymer network hydrogel film for salivary glucose monitoring
Nanoscale ( IF 5.8 ) Pub Date : 2020-10-09 , DOI: 10.1039/d0nr05854h Zifeng Zhang 1, 2, 3, 4, 5 , Qian Dou 1, 2, 3, 4, 5 , Shiwen Wang 5, 6, 7, 8, 9 , Debo Hu 5, 6, 7, 8, 9 , Bei Yang 5, 6, 7, 8, 9 , Zhipeng Zhao 5, 6, 7, 8, 9 , Hongliang Liu 4, 9, 10, 11 , Qing Dai 1, 2, 3, 4, 5
Nanoscale ( IF 5.8 ) Pub Date : 2020-10-09 , DOI: 10.1039/d0nr05854h Zifeng Zhang 1, 2, 3, 4, 5 , Qian Dou 1, 2, 3, 4, 5 , Shiwen Wang 5, 6, 7, 8, 9 , Debo Hu 5, 6, 7, 8, 9 , Bei Yang 5, 6, 7, 8, 9 , Zhipeng Zhao 5, 6, 7, 8, 9 , Hongliang Liu 4, 9, 10, 11 , Qing Dai 1, 2, 3, 4, 5
Affiliation
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Owing to its rapid response and broad detection range, a phenylboronic acid (PBA)-functionalized hydrogel film-coated quartz crystal microbalance (QCM) sensor is used to non-invasively monitor salivary glucose in diabetic patients. However, nonspecific protein adsorption on the PBA-functionalized hydrogel film can cause dramatic loss of sensitivity and accuracy of the sensor. A traditional zwitterionic polymer surface with ultra-low protein fouling can hinder the interaction of PBA in the hydrogel matrix with glucose molecules owing to its steric hindrance, resulting in poor glucose sensitivity of the sensor. Herein, we developed a novel hydrogel film that enhanced the antifouling properties and sensitivity of the QCM sensor by infiltrating a glucose-sensitive monomer (i.e., PBA) into a zwitterionic polymer brush matrix to form an interpenetrating polymer network (IPN). The IPN hydrogel film could minimize the glucose sensitivity loss since the antifouling polymer distributed in its matrix. Moreover, a stable hydration layer was formed in this film that could prevent water from transporting out of the matrix, thus further improving its antifouling properties and glucose sensitivity. The experimental results confirmed that the IPN hydrogel film possessed excellent resistance to protein fouling by mucin from whole saliva with reductions in adsorption of nearly 88% and could also enhance the glucose sensitivity by nearly 2 fold, compared to the PBA-functionalized hydrogel film. Therefore, the IPN hydrogel film provides improved antifouling properties and sensitivity of the QCM sensor, which paves the way for non-invasive monitoring of low concentrations of glucose in saliva.
中文翻译：
唾液葡萄糖监测防污互穿聚合物网络水凝胶膜的研制
由于其快速响应和广泛的检测范围，苯硼酸（PBA）功能化的水凝胶膜包裹的石英晶体微天平（QCM）传感器用于无创监测糖尿病患者的唾液葡萄糖。但是，非特异性蛋白质在PBA功能化的水凝胶膜上的吸附会导致传感器灵敏度和准确性的急剧下降。具有超低蛋白质结垢的传统两性离子聚合物表面由于其空间位阻而可能阻碍水凝胶基质中PBA与葡萄糖分子的相互作用，从而导致传感器对葡萄糖的敏感性较差。在这里，我们开发了一种新型的水凝胶薄膜，该薄膜通过渗入葡萄糖敏感性单体（即（PBA）转换成两性离子聚合物刷基体，形成互穿聚合物网络（IPN）。由于防污聚合物分布在其基质中，因此IPN水凝胶膜可将葡萄糖敏感性损失降至最低。而且，在该膜中形成了稳定的水合层，该水合层可以防止水从基质中运出，从而进一步提高了其防污性能和葡萄糖敏感性。实验结果证实，与PBA官能化的水凝胶膜相比，IPN水凝胶膜对粘蛋白从整个唾液中的蛋白质污染具有极好的抵抗力，吸附减少了近88％，还可以将葡萄糖敏感性提高近2倍。因此，IPN水凝胶薄膜可改善QCM传感器的防污性能和灵敏度，
更新日期：2020-11-12
中文翻译：
唾液葡萄糖监测防污互穿聚合物网络水凝胶膜的研制
由于其快速响应和广泛的检测范围，苯硼酸（PBA）功能化的水凝胶膜包裹的石英晶体微天平（QCM）传感器用于无创监测糖尿病患者的唾液葡萄糖。但是，非特异性蛋白质在PBA功能化的水凝胶膜上的吸附会导致传感器灵敏度和准确性的急剧下降。具有超低蛋白质结垢的传统两性离子聚合物表面由于其空间位阻而可能阻碍水凝胶基质中PBA与葡萄糖分子的相互作用，从而导致传感器对葡萄糖的敏感性较差。在这里，我们开发了一种新型的水凝胶薄膜，该薄膜通过渗入葡萄糖敏感性单体（即（PBA）转换成两性离子聚合物刷基体，形成互穿聚合物网络（IPN）。由于防污聚合物分布在其基质中，因此IPN水凝胶膜可将葡萄糖敏感性损失降至最低。而且，在该膜中形成了稳定的水合层，该水合层可以防止水从基质中运出，从而进一步提高了其防污性能和葡萄糖敏感性。实验结果证实，与PBA官能化的水凝胶膜相比，IPN水凝胶膜对粘蛋白从整个唾液中的蛋白质污染具有极好的抵抗力，吸附减少了近88％，还可以将葡萄糖敏感性提高近2倍。因此，IPN水凝胶薄膜可改善QCM传感器的防污性能和灵敏度，
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