Diverse Aromatic Metabolites in the Solitary Tunicate Cnemidocarpa irene,Journal of Natural Products

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Diverse Aromatic Metabolites in the Solitary Tunicate Cnemidocarpa irene
Journal of Natural Products ( IF 3.3 ) Pub Date : 2020-10-08 , DOI: 10.1021/acs.jnatprod.0c00789
Kei Miyako ₁ , Yoko Yasuno ₂ , Tetsuro Shinada ₂ , Masaki J Fujita ₁ , Ryuichi Sakai ₁

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Fourteen aromatic metabolites (6–19) were isolated from an aqueous extract of the solitary tunicate Cnemidocarpa irene collected in Hokkaido, Japan. The structures of the metabolites were determined based on the spectroscopic interpretations, including one- and two-dimensional NMR, mass spectra, UV, and circular dichroism data. The biopterin analogue 10 modulated the behavior of mice after intracerebroventricular injection and showed a weak affinity to ionotropic glutamate receptor subtypes. Analyses of fluorescent coelomic fluid of the tunicate revealed that pterin 12 was responsible for the fluorescence of the blood cells, while β-carbolines 1 and 3 were fluorescent compounds in the serum. The metabolic profiles in adults, juveniles, larvae, and eggs of the animal differed substantially, suggesting that the metabolism of the animal, especially biosynthesis of aromatic secondary metabolites, changes over different life stages.

中文翻译：

孤生被囊动物 Cnemidocarpa irene 中的多种芳香代谢物

从日本北海道收集的独生被囊动物Cnemidocarpa irene的水提取物中分离出 14 种芳香族代谢物 ( 6 – 19 )。代谢物的结构是根据光谱解释确定的，包括一维和二维核磁共振、质谱、紫外和圆二色性数据。生物蝶呤类似物10在脑室内注射后调节小鼠的行为，并且对离子型谷氨酸受体亚型表现出弱亲和力。对被囊动物荧光体腔液的分析表明，蝶呤12负责血细胞的荧光，而 β-咔啉1和3是血清中的荧光化合物。动物的成虫、幼虫、幼虫和卵的代谢特征存在显着差异，表明动物的代谢，特别是芳香次生代谢物的生物合成，在不同的生命阶段发生变化。

更新日期：2020-10-26

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