Bacteria-Inspired Nanomedicine,ACS Applied Bio Materials

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Bacteria-Inspired Nanomedicine
ACS Applied Bio Materials ( IF 4.6 ) Pub Date : 2020-10-08 , DOI: 10.1021/acsabm.0c01072
Maya Holay ₁ , Zhongyuan Guo ₁ , Jessica Pihl ₁ , Jiyoung Heo ₁ , Joon Ho Park ₁ , Ronnie H Fang ₁ , Liangfang Zhang ₁

Affiliation

The natural world has provided a host of materials and inspiration for the field of nanomedicine. By taking design cues from naturally occurring systems, the nanoengineering of advanced biomimetic platforms has significantly accelerated over the past decade. In particular, the biomimicry of bacteria, with their motility, taxis, immunomodulation, and overall dynamic host interactions, has elicited substantial interest and opened up exciting avenues of research. More recently, advancements in genetic engineering have given way to more complex and elegant systems with tunable control characteristics. Furthermore, bacterial derivatives such as membrane ghosts, extracellular vesicles, spores, and toxins have proven advantageous for use in nanotherapeutic applications, as they preserve many of the features from the original bacteria while also offering distinct advantages. Overall, bacteria-inspired nanomedicines can be employed in a range of therapeutic settings, from payload delivery to immunotherapy, and have proven successful in combatting both cancer and infectious disease.

中文翻译：

细菌启发的纳米医学

自然界为纳米医学领域提供了大量的材料和灵感。通过从自然存在的系统中获取设计线索，先进仿生平台的纳米工程在过去十年中显着加速。特别是，细菌的仿生学及其运动性、趋向性、免疫调节和整体动态宿主相互作用引起了人们的极大兴趣，并开辟了令人兴奋的研究途径。最近，基因工程的进步已经让位于具有可调控制特性的更复杂、更优雅的系统。此外，细菌衍生物，如膜影、细胞外囊泡、孢子和毒素，已被证明在纳米治疗应用中具有优势，因为它们保留了原始细菌的许多特征，同时还具有独特的优势。总体而言，细菌启发的纳米药物可用于从有效负载递送到免疫治疗的一系列治疗环境，并且已被证明在对抗癌症和传染病方面取得了成功。

更新日期：2020-10-08

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