Abstract Cancer phototheranostics in the second near-infrared window (NIR-II, 1000−1700 nm) has low tissue scattering and high permissive laser exposure. However, most of the few available theranostic agents in this spectral region suffer from thermal instability and poor programmability of absorption profiles. Here, we proposed a programmable method for the plasmonic modulation of gold nanotheranostics in the NIR-II window. By adjusting the sequences and concentrations of DNA templates, the localized surface plasmon resonance (LSPR) of gold theranostics successfully redshifts to the NIR-II window. The as-prepared gold nanodumbbells (AuNDs) possess good thermal stability, strong photoacoustic (PA) signals as well as high photothermal conversion efficiency (84.9 %). After conjugation with nucleolin-targeted DNA aptamer AS1411, the obtained targeted gold nanotheranostics (denoted as Ap-AuND) could perform effective NIR-II PA imaging-guided PTT for subcutaneous 4T1 tumors. Notably, the Ap-AuND-mediated NIR-II PTT significantly suppressed tumor growth and stimulated potent host antitumor immunity, resulting in significant inhibition of both distant tumor growth and whole-body spreading of tumor cells when combined with an anti-PDL1 antibody.

中文翻译：

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用于靶向 NIR-II 光热增强免疫治疗的金纳米治疗学的等离子体调制

摘要 第二个近红外窗口（NIR-II，1000-1700 nm）中的癌症光疗具有低组织散射和高允许激光照射。然而，在该光谱区域内为数不多的可用治疗诊断剂中的大多数都存在热不稳定性和吸收曲线可编程性差的问题。在这里，我们提出了一种在 NIR-II 窗口中对金纳米治疗学进行等离子体调制的可编程方法。通过调整 DNA 模板的序列和浓度，金治疗诊断学的局部表面等离子体共振 (LSPR) 成功地红移到 NIR-II 窗口。所制备的金纳米哑铃（AuNDs）具有良好的热稳定性、强光声（PA）信号以及高光热转换效率（84.9%）。与核素靶向 DNA 适体 AS1411 结合后，获得的靶向金纳米治疗学（表示为 Ap-AuND）可以对皮下 4T1 肿瘤进行有效的 NIR-II PA 成像引导 PTT。值得注意的是，Ap-AuND 介导的 NIR-II PTT 显着抑制了肿瘤生长并刺激了强大的宿主抗肿瘤免疫，当与抗 PDL1 抗体结合时，可显着抑制远处肿瘤生长和肿瘤细胞的全身扩散。