The spiro[chromane-2,4′-piperidine]-4(3H)-one is an important pharmacophore. It is a structural component in many drugs, drug candidates (or lead compounds) and various biochemical reagents. This review demonstrated an impressive progress in syntheses of spiro[chromane-2,4′-piperidine]-4(3H)-one-derived compoundsin the recent years and focuses on features of their biological relevance's. The prospects for the development of new biologically active substances containing a spiro[chromane-2,4′-piperidine]-4(3H)-one pharmacophore are analyzed and briefly discussed in terms of its structure, reaction, mechanism, scope and potential utility.

螺[铬烷-2,4'-哌啶] -4（3 H）-one是重要的药效团。它是许多药物，候选药物（或先导化合物）和各种生化试剂的结构成分。该综述证明了近年来合成螺并[铬烷-2,4'-哌啶] -4（3 H）-一的化合物取得了令人瞩目的进展，并着重介绍了它们的生物学相关性。含有螺并[苯并[ chromane -2,4'-哌啶] -4（3 H）的新型生物活性物质的开发前景）–分析并简要讨论了一种药效团的结构，反应，机理，范围和潜在用途。