Fe-TCPP@CS nanoparticles as photodynamic and photothermal agents for efficient antimicrobial therapy,Biomaterials Science

当前位置： X-MOL 学术 › Biomater. Sci. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Fe-TCPP@CS nanoparticles as photodynamic and photothermal agents for efficient antimicrobial therapy
Biomaterials Science ( IF 5.8 ) Pub Date : 2020-10-08 , DOI: 10.1039/d0bm01427c
Yufeng Zhang _{1,

2,

3,

4,

5} , Jing Ma _{1,

2,

3,

4,

5} , Dianwei Wang _{3,

4,

5,

6,

7} , Caina Xu _{3,

4,

5,

6,

7} , Shu Sheng _{3,

4,

5,

6,

7} , Jianfeng Cheng _{1,

2,

3,

4} , Changjiang Bao _{1,

2,

3,

4} , Yanhui Li _{1,

2,

3,

4} , Huayu Tian _{3,

4,

5,

6,

7}

Affiliation

Traditional antimicrobial therapies always rely on antibiotics, which have led to the overuse of antibiotics and caused the emergence of multidrug-resistant (MDR) bacteria in recent years. In this study, an efficient and broad-spectrum antimicrobial system based on chitosan (CS)-encapsulated multifunctional metal–organic nanoparticles (Fe-TCPP@CS NPs) was constructed to integrate the electrostatic targeting property and photodynamic and photothermal antimicrobial therapies. Tetrakis (4-carboxyphenyl) porphyrin (TCPP) coordinated with Fe₃O clusters to form nanoparticles, Fe₃O clusters enabled low-temperature photothermal therapy as well as avoiding the porphyrins self-aggregation to ensure the singlet oxygen yield under irradiation, and CS as the outer layer covered on Fe-TCPP nanoparticles could improve the dispersibility in aqueous solution and enhance the electrostatic binding with bacterial cell membranes to improve the antibacterial activities. After simple synthesis, we successfully obtained ideal and biocompatible multifunctional nanoparticles and verified their antimicrobial properties. Under light irradiation, Fe-TCPP@CS NPs could produce enough ROS and heat to kill S. aureus, E. coli and methicillin-resistant S. aureus with a synergistic effect. Therefore, Fe-TCPP@CS NPs would be an efficient and broad-spectrum antimicrobial agent, providing a novel approach to bacterial infection therapy.

中文翻译：

Fe-TCPP @ CS纳米粒子作为光动力剂和光热剂，可有效进行抗菌治疗

传统的抗微生物疗法始终依靠抗生素，这导致了抗生素的过度使用，并导致近年来出现了多药耐药性（MDR）细菌。在这项研究中，构建了一种基于壳聚糖（CS）封装的多功能金属有机纳米粒子（Fe-TCPP @ CS NPs）的高效且广谱的抗菌系统，以整合静电靶向特性以及光动力和光热抗菌疗法。四（4-羧基苯基）卟啉（TCPP）与Fe ₃ O团簇配合形成纳米颗粒Fe ₃O团簇使低温光热疗法成为可能，并且避免了卟啉的自聚集，从而确保辐照下的单线态氧产量；而CS作为Fe-TCPP纳米颗粒上覆盖的外层可以改善水溶液中的分散性并增强静电结合具有细菌细胞膜，提高抗菌活性。通过简单的合成，我们成功获得了理想的生物相容性多功能纳米颗粒，并验证了其抗菌性能。在光照射下，Fe-TCPP @ CS NP可以产生足够的ROS和热量来杀死金黄色葡萄球菌，大肠杆菌和耐甲氧西林的金黄色葡萄球菌具有协同作用。因此，Fe-TCPP @ CS NPs将是一种有效且广谱的抗菌剂，为细菌感染治疗提供了一种新颖的方法。

更新日期：2020-11-03

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南