A pair of new macrocyclic spermidine alkaloids, (+)-(S)-scocycamide and (−)-(R)-scocycamide, were isolated from the roots of Scopolia tangutica. Their structures were established by extensive spectroscopic data, electronic circular dichroism analyses, and chemical synthesis. They featured a unique 6/18 fused bicyclic framework with spermidine and catechol units, representing a new subtype of natural spermidine alkaloids. A plausible biosynthetic pathway was also proposed. They inhibited butyrylcholinesterase and exhibited antioxidant capacity, suggesting beneficial constituents against Alzheimer’s disease and oxidation.

中文翻译：

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Scocycamides，一对具有丁酰胆碱酯酶抑制和抗氧化活性的大环双咖啡酰亚精胺，来自东莨菪子的根

一对新的大环亚精胺生物碱，(+)-( S )-scocycamide 和(-)-( R )-scocycamide，是从Scopolia tangutica的根中分离出来的。它们的结构是通过广泛的光谱数据、电子圆二色性分析和化学合成建立的。它们具有独特的 6/18 稠合双环骨架，具有亚精胺和儿茶酚单元，代表了天然亚精胺生物碱的新亚型。还提出了一种合理的生物合成途径。它们抑制丁酰胆碱酯酶并表现出抗氧化能力，表明它们是对抗阿尔茨海默病和氧化的有益成分。