As populations age, the prevalence of reported drug “allergy” increases, often leading to suboptimal care and increased morbidity because of unnecessary avoidance of safe and effective medications. Evaluation by a drug allergy specialist is often warranted when a patient has more than 2 unrelated drug “allergies” listed in the medical record. In this commentary, we clarify and propose standard terminology to use when evaluating patients with multiple drug allergy labels including and more specifically when diagnosing multiple drug intolerance syndrome and the much rarer multiple drug hypersensitivity syndrome. We review epidemiology and key features of multiple drug intolerance syndrome and multiple drug hypersensitivity syndrome. We summarize the methodologic and practical diagnostic workup and management of individuals with MDIS to assist with the accurate delabeling of drug “allergies” in the electronic health record.

随着人口的老龄化，所报告的药物“过敏”的患病率增加，由于不必要地避免使用安全有效的药物，常常导致护理不佳和发病率增加。当患者的病历中列出了两种以上无关的药物“过敏”时，通常需要由药物过敏专家进行评估。在这篇评论中，我们阐明并提出了用于评估具有多种药物过敏标签的患者的标准术语，包括尤其是在诊断多种药物不耐受综合征和罕见的多种药物超敏反应综合征时。我们审查了多药不耐受综合征和多药超敏反应综合征的流行病学和关键特征。