Purpose

To investigate the safety and effectiveness of superselective prostatic artery embolization (PAE) in patients with benign prostatic hyperplasia (BPH).

Methods

Sixty-five patients diagnosed with BPH in Fujian Provincial Hospital between December 2014 and July 2019 were included. Patients with ineffective drug treatment after 6 months, who refused surgery, or who were unsuitable for surgery were included. We observed postoperative complications, followed up at 1, 3, and 6 months, compared clinical symptoms, and monitored changes in prostate-specific antigen (PSA) and prostatic volume (PV) before and after treatment.

Results

Of the 65 patients, 58 (89.23%) successfully received PAE; 44 and 14 bilateral and unilateral embolization, respectively. Clinical efficacy was 94.83% (55/58) after the 6-month follow-up. Postoperative PV, International Prostate Symptom Score, quality of life, maximum flow rate, and post-void residual significantly improved after 6 months (P < 0.05). One month after PAE, the serum total PSA increased by 1.47 (10.84/7.37) times and dropped 3 months later to a level lower than that before surgery (P < 0.05). Six months after PAE, the degree of relief from obstructive symptoms was more apparent than that of irritative symptoms. No serious complications were observed after PAE.

Conclusion

PAE was safe and effective for the treatment of BPH. The efficacy of bilateral PAE was better than that of unilateral PAE.

中文翻译：

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超选择性前列腺动脉栓塞术对良性前列腺增生的影响

目的

探讨超选择性前列腺动脉栓塞术（PAE）治疗良性前列腺增生（BPH）的安全性和有效性。

方法

纳入2014年12月至2019年7月在福建省立医院诊断为BPH的患者65例。包括6个月后药物治疗无效、拒绝手术或不适合手术的患者。我们观察术后并发症，在 1、3 和 6 个月时进行随访，比较临床症状，并监测治疗前后前列腺特异性抗原 (PSA) 和前列腺体积 (PV) 的变化。

结果

65 名患者中，58 名（89.23%）成功接受 PAE；双侧和单侧栓塞分别为 44 和 14。6个月随访后临床有效率为94.83%（55/58）。术后 PV、国际前列腺症状评分、生活质量、最大流量和术后残余尿量在 6 个月后显着改善（P  < 0.05）。PAE后1个月，血清总PSA升高1.47（10.84/7.37）倍，3个月后降至术前水平（P  < 0.05）。PAE后6个月，阻塞症状的缓解程度比刺激症状的缓解程度更明显。PAE后未观察到严重并发症。

结论

PAE治疗BPH安全有效。双侧PAE的疗效优于单侧PAE。