Graphitic Carbon Nitride Quantum Dots Embedded in Carbon Nanosheets for Near-Infrared Imaging-Guided Combined Photo-Chemotherapy,ACS Nano

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Graphitic Carbon Nitride Quantum Dots Embedded in Carbon Nanosheets for Near-Infrared Imaging-Guided Combined Photo-Chemotherapy
ACS Nano ( IF 15.8 ) Pub Date : 2020-10-05 , DOI: 10.1021/acsnano.0c05143
Hongji Liu _{1,

2,

3} , Xiaotong Lv _{1,

2,

4} , Junchao Qian ₅ , Hong Li _{1,

4} , Yong Qian _{1,

3} , Xingyu Wang _{1,

2,

3} , Xiangfu Meng _{1,

2,

3} , Wenchu Lin _{1,

4} , Hui Wang _{1,

3,

4}

Affiliation

Rational design of metal-free multifunctional therapeutic reagents offers great opportunities for cancer treatment in the clinic. Here, graphitic carbon nitride (g-C₃N₄) quantum dots embedded in carbon nanosheets (CNQD-CN) are in situ prepared via a one-pot hydrothermal approach with formamide as carbon and nitrogen source. The CNQD-CN not only serves as an excellent near-infrared (NIR) fluorescent marker but also acts as a pH-responsive nanocarrier. Moreover, the CNQD-CN possesses both light-to-heat conversion and singlet oxygen generation capabilities under a single NIR excitation wavelength. Further investigations show that systemic delivery of doxorubicin (DOX) using the multifunctional CNQD-CN nanocarrier under NIR irradiation was highly effective to cause cancer cell apoptosis in vitro and inhibit tumor growth in vivo. CNQD-CN represents a multifunctional therapeutic platform for synchronous cancer imaging and treatment through the synergistic effect of phototherapy and chemotherapy.

中文翻译：

嵌入碳纳米片中的石墨化氮化碳量子点，用于近红外成像引导的联合光化学疗法

合理设计的无金属多功能治疗剂为临床癌症治疗提供了巨大的机会。在这里，通过碳纳米管（CNQD-CN）原位制备嵌入在碳纳米片（CNQD-CN）中的石墨氮化碳（gC ₃ N ₄）量子点。一种以甲酰胺为碳源和氮源的单锅水热法。CNQD-CN不仅可以用作出色的近红外（NIR）荧光标记，而且还可以作为pH响应纳米载体。此外，CNQD-CN在单个NIR激发波长下具有光热转换和单线态氧生成的能力。进一步的研究表明，使用多功能CNQD-CN纳米载体在近红外辐射下全身递送阿霉素（DOX）在体外引起癌细胞凋亡并在体内抑制肿瘤生长方面非常有效。CNQD-CN通过光疗和化学疗法的协同作用，代表了一种用于同步癌症成像和治疗的多功能治疗平台。

更新日期：2020-10-28

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