Biosynthetic Technologies 6320 Intech Way Indianapolis IN 46278 USA
Department of Chemistry and Biochemistry Loyola University Chicago Chicago IL 60660 USA
Regis Technologies, Inc. 8210 Austin Ave. Morton Grove Illinois 60053 USA
Department of Chemistry and Biochemistry Northern Illinois University DeKalb IL 60115 USA
前盖显示理想化的细胞，正常细胞以右半部分表示，表面有细胞器和各种受体，而肿瘤细胞则以无序的左半部分表示。含碳硼烷的基质金属蛋白酶（MMP）抑制剂/配体包围着健康细胞和肿瘤细胞，但与肿瘤表面过表达的明胶酶（MMP-2和MMP-9）有效结合。从左侧进入的热中子在碳硼烷簇中的10 B原子中发现了代表的靶心，导致亚稳11 B经历了裂变释放α和7会破坏并最终破坏肿瘤细胞靶标的锂粒子。封面设计由Robert D. Becker设计。更多信息可以在Daniel P. Becker等人的论文全文中找到。
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Front Cover: Carborane‐Containing Matrix Metalloprotease (MMP) Ligands as Candidates for Boron Neutron‐Capture Therapy (BNCT) (ChemMedChem 20/2020)
The Front Cover shows an idealized cell with a normal cell represented by the right half, with organelles and a variety of receptors on the surface, whereas a tumor cell is represented by the disordered left half of the cell. The carborane‐containing matrix metalloproteinase (MMP) inhibitor/ligand surrounds both healthy and tumor cells, but binds potently to the overexpressed gelatinase (MMP‐2 and MMP‐9) enzymes on the tumor surface. Incoming thermal neutrons from the left find the represented bullseye in the 10B atoms in the carborane cluster leading to a metastable 11B that undergoes fission releasing α and 7Li particles that damage and ultimately destroy the tumor cell target. Cover design by Robert D. Becker. More information can be found in the Full Paper by Daniel P. Becker et al.
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