Ciprofloxacin (CIP) is the most prescribed antibiotic worldwide and is considered an emerging contaminant. The adsorption of ciprofloxacin onto calcined Verde-lodo (CVL) bentonite clay in a static system was evaluated in this study. CVL clay was characterized by Fourier Transform Infrared Spectroscopy, X-ray Diffraction, Thermogravimetric Analysis, and Zeta analyzer before and after application to examine the adsorption mechanism. Statistical techniques of experimental design were used to determine the best conditions to maximize the adsorption capacity of CIP. Static system tests were performed to evaluate the kinetics, isotherm, and thermodynamics of adsorption. The system reached a maximum Langmuir removal capacity (25 °C) of 114.4 mg g^-1 and CVL clay displayed considerable reuse capacity with heat treatment at 500 °C. The ability for regeneration and high removal capacity of CVL provides a promising strategy to mitigate emerging contaminants present in wastewater.