Euphopias A–C: Three Rearranged Jatrophane Diterpenoids with Tricyclo[8.3.0.02,7]tridecane and Tetracyclo[11.3.0.02,10.03,7]hexadecane Cores from Euphorbia helioscopia,Organic Letters

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Euphopias A–C: Three Rearranged Jatrophane Diterpenoids with Tricyclo[8.3.0.02,7]tridecane and Tetracyclo[11.3.0.02,10.03,7]hexadecane Cores from Euphorbia helioscopia
Organic Letters ( IF 4.9 ) Pub Date : 2020-09-29 , DOI: 10.1021/acs.orglett.0c02676
Qiang-Qiang Shi ₁ , Xing-Jie Zhang ₁ , Ting-Ting Wang ₁ , Qi Wang ₁ , Tian-Tian Sun ₁ , Muhammad Amin ₁ , Rui-Han Zhang ₁ , Xiao-Li Li ₁ , Wei-Lie Xiao ₁

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Euphopias A–C (1–3), three rearranged jatrophane-type diterpenoids with tricyclo[8.3.0.0^2,7]tridecane (1 and 2) and tetracyclo[11.3.0.0^2,10.0^3,7]hexadecane (3) cores, were isolated from Euphorbia helioscopia. Comprehensive spectroscopic analyses, quantum-chemical calculations, and X-ray diffractions were used to identify their structures. Compounds 1–3 could significantly inhibit NLRP3 inflammasome activation and block NLRP3 inflammasome-induced pyroptosis. Additionally, a mechanistic study revealed that 2 could ameliorate mitochondria damage, thereby interrupting NLRP3 inflammasome activation.

中文翻译：

Euphopias A–C：来自大戟属植物的三环[8.3.0.02,7]十三烷和四环[11.3.0.02,10.03,7]十六烷核心的三种重排麻风树二萜类化合物

Euphopias A–C ( 1 – 3 )，三个重排麻风树型二萜与三环[8.3.0.0 ^2,7 ]十三烷（1和2）和四环[11.3.0.0 ^2,10 .0 ^3,7 ]十六烷（3 ) 核，是从Euphorbia helioscopia中分离出来的。综合光谱分析、量子化学计算和 X 射线衍射用于识别它们的结构。化合物1 - 3可以显著禁止NLRP3炎性活化和块NLRP3炎性诱导pyroptosis。此外，一项机理研究表明，2 可以改善线粒体损伤，从而中断 NLRP3 炎症小体的激活。

更新日期：2020-10-17

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