A series of novel 6‐substituted 2‐(benzo[4,5]imidazo[1,2‐c]quinazolin‐5(6H)‐yl)acetic acids were synthesized and characterized by ¹H, ¹³C, ¹⁹F NMR, ¹H‐¹H‐COSY, ¹H‐¹³C‐HSQC, NOESY, LC‐MS, IR, and elemental analysis. The mitotic toxicity of the synthesized compounds was determined according to the Allium test procedure. The 2‐(6‐(pentafluorophenyl)benzo[4,5]imidazo[1,2‐c]quinazolin‐5(6H)‐yl)acetic acid inhibited mitotic spindle formation, which resulted in significant cytotoxic effect for meristematic cells of Allium cepa l. roots. In a preliminary antimicrobial evaluation, only Streptococcus pyogenes and Candida albicans were slightly susceptible to some of the synthesized compounds.

中文翻译：

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新型6-取代的2-（苯并[4,5]咪唑并[1,2-c]喹唑啉-5（6H）-基）乙酸的合成，抗菌和有丝分裂毒性评估

合成了一系列新颖的6-取代的2-（苯并[4,5]咪唑并[1,2 - c ]喹唑啉-5（6 H）-基）乙酸，并通过¹ H，¹³ C，¹⁹ F NMR表征，¹ H- ¹ H-COSY，¹ H- ¹³ C-HSQC，NOESY，LC-MS，IR和元素分析。根据葱属测试方法确定合成化合物的有丝分裂毒性。2-（6-（五氟苯基）苯并[4,5]咪唑并[1,2 - c ]喹唑啉-5（6 H）-基）乙酸抑制有丝分裂纺锤体的形成，对分生组织细胞产生明显的细胞毒性作用洋葱 升。根。在初步的抗菌评估中，只有化脓性链球菌和白色念珠菌对某些合成化合物略有敏感性。