Aiming at deficiencies in non-degradable stents for benign common bile duct obstruction, the magnesium (Mg)-based braided stents were developed with one monofilament as a pilot research in this paper. We designed stents with the different monofilament diameter, braided-pin number and surface treatment systematically to study the mechanical and degradation behaviors. The results suggest the fluorinated Mg stents and them with polycaprolactone (PCL) coating can achieve the compression force of 3.35–11.07 N and 11.09–24.08 N, and even maintain 3.10–10.43 N for 3 days immersion and 3.11–9.37 N for 20 days immersion respectively. PCL coating on monofilament can provide significantly better compression force and corrosion resistance. By comparison with the stent in clinic, these Mg stents are expected to meet the demand of the radial compression force and implantation time. Furthermore, the degradation occurs at the ends preferentially for all stents, but for stents without PCL coating, the intersections of wire-mesh are also the area easily corroded. Additionally, the result of the compression test indicates the radial compression force is improved with the increase of monofilament diameter and pins number, but the recovery capability decreases slightly.

中文翻译：

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用于胆道重建的可生物降解编织镁支架的研究

针对良性胆总管梗阻不可降解支架的不足，本文以单丝为先导研究开发了镁（Mg）基编织支架。我们系统地设计了具有不同单丝直径、编织针数和表面处理的支架，以研究其机械和降解行为。结果表明，氟化镁支架和聚己内酯（PCL）涂层可以实现3.35-11.07 N和11.09-24.08 N的压缩力，甚至可以保持3.10-10.43 N浸泡3天和3.11-9.37 N浸泡20天分别沉浸。单丝上的 PCL 涂层可以提供明显更好的压缩力和耐腐蚀性。与临床上的支架相比，这些镁支架有望满足径向压缩力和植入时间的需求。此外，所有支架的降解都优先发生在末端，但对于没有PCL涂层的支架，丝网交叉处也是容易腐蚀的区域。另外，压缩试验结果表明，径向压缩力随着单丝直径和针数的增加而提高，但恢复能力略有下降。