Highland Barley Whole Grain (Hordeum vulgare L.) Ameliorates Hyperlipidemia by Modulating Cecal Microbiota, miRNAs, and AMPK Pathways in Leptin Receptor-Deficient db/db Mice,Journal of Agricultural and Food Chemistry

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Highland Barley Whole Grain (Hordeum vulgare L.) Ameliorates Hyperlipidemia by Modulating Cecal Microbiota, miRNAs, and AMPK Pathways in Leptin Receptor-Deficient db/db Mice
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2020-09-27 , DOI: 10.1021/acs.jafc.0c04780
Na Deng ₁ , Ziqian He ₁ , Ruixue Guo ₂ , Bisheng Zheng _{1,

3} , Tong Li ₄ , Rui Hai Liu ₄

Affiliation

The mechanisms of highland barley whole grain (BWG) with rich phenolics on obese db/db mice were investigated in this study. Oral consumption of BWG reduced food intake, body weight, organ/body weight indexes of liver and fat, levels of serum and hepatic lipids, liver injury, and oxidative stress. Furthermore, BWG recovered the disorder of cecal microbiota by augmenting the Bacteroidetes/Firmicutes ratio and Alistipes abundance and decreasing the abundances of Bacteroides and Desulfovibrionaceae to modulate lipid metabolism-related genes. BWG inhibited fatty acid biosynthesis via upregulating the phosphorylation of AMP-activated protein kinase α, while downregulating sterol regulatory element binding protein-1c, fatty acid synthase (FAS), and stearoyl-CoA desaturase 1 levels. BWG also significantly downregulated miRNA-122, miRNA-33, miRNA-34a, and miRNA-206 levels. Accordingly, BWG exhibited hypolipidemic potential through modulating cecal microbiota, AMPK/SREBP-1c/FAS pathway, and related miRNAs, triggering the alleviation of dyslipidemia. These findings suggested BWG as an effective candidate to ameliorate the symptoms of hyperlipidemia.

中文翻译：

高地大麦全谷物（大麦L.）通过调节盲肠受体缺陷型db / db小鼠的盲肠微生物群，miRNA和AMPK途径改善高脂血症

本研究探讨了高脂大麦全麦（BWG）对肥胖db / db小鼠的作用机理。口服BWG可减少食物摄入量，体重，肝脏和脂肪的器官/体重指数，血清和肝脂质的水平，肝损伤和氧化应激。此外，BWG通过增加拟杆菌（Bacteroidetes） /硬毛菌（Finictices）比例和Alistipes丰度，并降低了拟杆菌（Bacteroides）和脱硫弧菌（Desulfovibrionaceae）的丰度来恢复盲肠微生物群的疾病。调节脂质代谢相关基因。BWG通过上调AMP激活的蛋白激酶α的磷酸化来抑制脂肪酸的生物合成，同时下调固醇调节元件结合蛋白1c，脂肪酸合酶（FAS）和硬脂酰-CoA去饱和酶1的水平。BWG还显着下调了miRNA-122，miRNA-33，miRNA-34a和miRNA-206的水平。因此，BWG通过调节盲肠微生物群，AMPK / SREBP-1c / FAS途径和相关的miRNA表现出降血脂的潜力，从而触发了血脂异常的缓解。这些发现表明BWG是改善高脂血症症状的有效候选者。

更新日期：2020-10-21

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