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The neuropharmacology of cannabinoid receptor ligands in central signaling pathways
European Journal of Neuroscience ( IF 2.7 ) Pub Date : 2020-09-24 , DOI: 10.1111/ejn.14982 Tibor M Brunt 1 , Matthijs G Bossong 2
European Journal of Neuroscience ( IF 2.7 ) Pub Date : 2020-09-24 , DOI: 10.1111/ejn.14982 Tibor M Brunt 1 , Matthijs G Bossong 2
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The endocannabinoid system is a complex neuronal system involved in a number of biological functions, like attention, anxiety, mood, memory, appetite, reward, and immune responses. It is at the centre of scientific interest, which is driven by therapeutic promise of certain cannabinoid ligands and the changing legalization of herbal cannabis in many countries. The endocannabinoid system is a modulatory system, with endocannabinoids as retrograde neurotransmitters rather than direct neurotransmitters. Neuropharmacology of cannabinoid ligands in the brain can therefore be understood in terms of their modulatory actions through other neurotransmitter systems. The CB1 receptor is chiefly responsible for effects of endocannabinoids and analogous ligands in the brain. An overview of the neuropharmacology of several cannabinoid receptor ligands, including endocannabinoids, herbal cannabis and synthetic cannabinoid receptor ligands is given in this review. Their mechanism of action at the endocannabinoid system is described, mainly in the brain. In addition, effects of cannabinoid ligands on other neurotransmitter systems will also be described, such as dopamine, serotonin, glutamate, noradrenaline, opioid, and GABA. In light of this, therapeutic potential and adverse effects of cannabinoid receptor ligands will also be discussed.
中文翻译：
中枢信号通路中大麻素受体配体的神经药理学
内源性大麻素系统是一个复杂的神经元系统，涉及许多生物学功能，如注意力、焦虑、情绪、记忆、食欲、奖励和免疫反应。它是科学兴趣的中心，这是由某些大麻素配体的治疗前景和许多国家不断变化的草药大麻合法化推动的。内源性大麻素系统是一个调节系统，内源性大麻素作为逆行神经递质而不是直接神经递质。因此，可以根据它们通过其他神经递质系统的调节作用来理解大脑中大麻素配体的神经药理学。CB 1受体主要负责内源性大麻素和类似配体在大脑中的作用。本综述概述了几种大麻素受体配体的神经药理学，包括内源性大麻素、草本大麻和合成大麻素受体配体。描述了它们在内源性大麻素系统中的作用机制，主要在大脑中。此外，还将描述大麻素配体对其他神经递质系统的影响，例如多巴胺、血清素、谷氨酸、去甲肾上腺素、阿片类药物和 GABA。有鉴于此，还将讨论大麻素受体配体的治疗潜力和副作用。
更新日期：2020-09-24
中文翻译：
中枢信号通路中大麻素受体配体的神经药理学
内源性大麻素系统是一个复杂的神经元系统，涉及许多生物学功能，如注意力、焦虑、情绪、记忆、食欲、奖励和免疫反应。它是科学兴趣的中心，这是由某些大麻素配体的治疗前景和许多国家不断变化的草药大麻合法化推动的。内源性大麻素系统是一个调节系统，内源性大麻素作为逆行神经递质而不是直接神经递质。因此，可以根据它们通过其他神经递质系统的调节作用来理解大脑中大麻素配体的神经药理学。CB 1受体主要负责内源性大麻素和类似配体在大脑中的作用。本综述概述了几种大麻素受体配体的神经药理学，包括内源性大麻素、草本大麻和合成大麻素受体配体。描述了它们在内源性大麻素系统中的作用机制，主要在大脑中。此外，还将描述大麻素配体对其他神经递质系统的影响，例如多巴胺、血清素、谷氨酸、去甲肾上腺素、阿片类药物和 GABA。有鉴于此，还将讨论大麻素受体配体的治疗潜力和副作用。
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