Amidation Reaction of Quinoline‐3‐carboxylic Acids with Tetraalkylthiuram Disulfides under Simple Conditions: A facile Synthesis of Quinoline‐3‐carboxamides,Asian Journal of Organic Chemistry

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Amidation Reaction of Quinoline‐3‐carboxylic Acids with Tetraalkylthiuram Disulfides under Simple Conditions: A facile Synthesis of Quinoline‐3‐carboxamides
Asian Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2020-09-24 , DOI: 10.1002/ajoc.202000462
Jingyan Hu ₁ , Xiefeng Ye ₁ , Shuai Hao ₁ , Qianrui Zhao ₁ , Mingqin Zhao ₁ , Yuewei Wei ₁ , Zhiyong Wu ₂ , Na Wang ₃ , Xiaoming Ji ₁

Affiliation

A highly efficient and simple procedure for the synthesis quinoline‐3‐carboxamides and their analogues via amidation reaction of quinoline‐3‐carboxylic acids with tetraalkylthiuram disulfides has been developed. The reaction proceeds efficiently under simple reaction conditions and features the generality of broad scope of substrates with good yields. This protocol provides a convenient procedure for the synthesis of various aza‐heteroaromatic carboxamides, which is of pharmaceutical interest.

中文翻译：

喹啉-3-羧酸与四烷基秋兰姆二硫化物在简单条件下的酰胺化反应：喹啉-3-羧酰胺的简便合成

通过喹啉-3-羧酸与四烷基秋兰姆二硫化物的酰胺化反应，开发了一种高效，简单的喹啉-3-羧酰胺及其类似物合成方法。该反应在简单的反应条件下有效地进行，并且具有广泛范围的底物具有高收率的一般性。该方案为合成各种具有医药意义的氮杂杂芳族羧酰胺提供了便利的程序。

更新日期：2020-09-24

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