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Crystal Structures and Spectroscopic Characterization of Four Synthetic Cathinones: 1-(4-Chlorophenyl)-2-(Dimethylamino)Propan-1-One (N-Methyl-Clephedrone, 4-CDC), 1-(1,3-Benzodioxol-5-yl)-2-(Tert-Butylamino)Propan-1-One (tBuONE, Tertylone, MDPT), 1-(4-Fluorophenyl)-2-(Pyrrolidin-1-yl)Hexan-1-One (4F-PHP) and 2-(Ethylamino)-1-(3-Methylphenyl)Propan-1-One (3-Methyl-Ethylcathinone, 3-MEC)
Crystals ( IF 2.4 ) Pub Date : 2019-10-24 , DOI: 10.3390/cryst9110555
Marta Siczek , Miłosz Siczek , Paweł Szpot , Marcin Zawadzki , Olga Wachełko

Every year new synthetic cathinones are flooding the European drug market. They gain more and more popularity in place of cathinones that became illegal. Compounds from both groups, “classic” and “new” cathinones, have a similar chemical structure and, as a consequence, their psychoactive properties are not much different. Cathinone analogs were secured by the police during the search of a suspect’s apartment. The aim of this paper was to present results of analyses and identification of these synthetic cathinones. The structure of new psychoactive substances (NPS) was identified by single-crystal X-ray analysis, solution nuclear magnetic resonance (NMR), UHPLC-QQQ-MS/MS and GC-MS.

中文翻译:

四种合成Cathinones的晶体结构和光谱表征:1-(4-氯苯基)-2-(二甲基氨基)丙-1-酮(N-甲基-乙二酮,4-CDC),1-(1,3-苯并二恶唑-5 -基)-2-(叔丁基氨基)丙烷-1-一(tBuONE,替丁酮,MDPT),1-(4-氟苯基)-2-(吡咯烷-1-基)己聚糖-1-一(4F-PHP )和2-(乙基氨基)-1-(3-甲基苯基)丙烷-1-一(3-甲基乙基卡西酮,3-MEC)

每年,新的合成卡西酮席卷欧洲药物市场。他们越来越成为非法的卡西酮,越来越受欢迎。两组化合物,“经典”和“新”卡西酮,具有相似的化学结构,因此,它们的精神活性相差无几。Cathinone类似物在搜查嫌疑人的公寓时受到警察的保护。本文的目的是提出分析和鉴定这些合成卡西酮的结果。通过单晶X射线分析,溶液核磁共振(NMR),UHPLC-QQQ-MS / MS和GC-MS鉴定了新型精神活性物质(NPS)的结构。
更新日期:2019-10-24
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