Current Organic Chemistry ( IF 1.7 ) Pub Date : 2014-05-01 , DOI: 10.2174/1385272819666140201003050 Sunil Singh , Vivek Sharma
This review provides a comprehensive compilation of available literature concerning the reactions of 1,2- & 1,4- dihydropyridines, which have opened new frontiers in the area of synthetic and medicinal chemistry. These reactions mainly include cycloaddition, 1,3-Dipolar cycloaddition, alkoxy halogenation, diamination, hydroxyamination, oxidation, hydroxylation, photooxygenation reaction, nucleophilic addition, cyclization, electrophilic substitution, multicomponent reactions (MCRs) and rearrangement reactions. 1,4-Dihydropyridine has also been used in hydrogen transfer reactions as a synthetic NADH model for the reduction of several important molecules in excellent yields.
中文翻译:
1,2-和1,4-二氢吡啶的反应
这篇综述提供了有关1,2-和1,4-二氢吡啶反应的现有文献的详尽汇编,这些文献在合成和药物化学领域开辟了新的领域。这些反应主要包括环加成反应,1,3-偶极环加成反应,烷氧基卤化,双氨基化,羟基氨基化,氧化,羟基化,光氧合反应,亲核加成,环化,亲电取代,多组分反应(MCR)和重排反应。1,4-二氢吡啶也已用于氢转移反应中,作为合成的NADH模型,用于以优异的产率还原多个重要分子。