Background: During the last decade, numerous research has indicated a promising perspective for selenophene and benzo[b]selenophene (BBS) as a promising scaffold for biologically active compounds. Selenophene is regarded as a bioisostere of benzene, hence numerous of selenophene derivatives have been synthesized to imitate the biological activities of benzene-containing analogues. Benzo[b]selenophene is regarded as a bioisostere of naphthalene, benzo[b]furan, benzo[b]thiophene, and indole. The main approach to the discovery of new biologically active BBS derivatives is based on the synthesis of selenium analogues of already known bioactive molecules.

Objective: The recent interest of introducing selenium for biologically active compounds may arise from the fact that the selenium is a very useful element. In this review, we are presenting the biological activities described for functionalized selenophenes and benzoselenophenes.

Conclusion: We could show in this review the biological future for selenophenes and benzo[b]selenophenes. Several selenophenes have been studied for different biological activities especially in the field of cancer treatment. For benzoselenophenes, the results of the most recent studies predict promising future in the field of medicinal chemistry. These activities are varying mainly between antioxidant and antitumor.

背景：在过去的十年中，大量研究表明硒硒和苯并[b]硒烯（BBS）作为具有生物活性化合物的有前途的支架的前景广阔。硒烯被认为是苯的生物等排体，因此已经合成了许多硒烯衍生物以模仿含苯类似物的生物活性。苯并[b]硒烯被认为是萘，苯并[b]呋喃，苯并[b]噻吩和吲哚的生物等排体。发现新的生物活性BBS衍生物的主要方法是基于已知生物活性分子的硒类似物的合成。

目的：引入硒作为生物活性化合物的最新兴趣可能来自硒是非常有用的元素这一事实。在这篇综述中，我们介绍了功能化硒烯和苯并硒烯的生物活性。

结论：我们可以在本综述中显示硒代苯酚和苯并[b]硒代苯酚的生物学前景。已经研究了几种硒代苯酚具有不同的生物活性，尤其是在癌症治疗领域。对于苯并硒吩，最新研究结果预测了药物化学领域的广阔前景。这些活性主要在抗氧化剂和抗肿瘤之间变化。