Various 6-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine derivatives (3a-3n) were designed keeping in view the wide bioactivities of 1,2,4-triazoles and their fused heterocyclic derivatives. All target compounds 3a-3n, characterized by IR, 1H-NMR and MS, have been evaluated for their anticonvulsant activity against MES-induced seizures. The pharmacological results showed that most of the compounds displayed some degree of anticonvulsant activity. Among them, 6-(4-chlorophenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine (3h) was the most promising compound with an ED50 value of 40.9 mg/kg and a PI value of 6.5.

考虑到1,2,4的广泛生物活性，设计了各种6-苯基-7H- [1,2,4]三唑并[3,4-b] [1,3,4]噻二嗪衍生物（3a-3n）。 -三唑及其稠合的杂环衍生物。已对所有以IR，1H-NMR和MS为特征的目标化合物3a-3n进行了抗MES诱发癫痫发作的抗惊厥活性的评估。药理结果表明，大多数化合物显示出一定程度的抗惊厥活性。其中6-（4-氯苯基）-7H- [1,2,4]三唑[3,4-b] [1,3,4]噻二嗪（3h）是最有前途的化合物，ED50值为40.9 mg / kg，PI值为6.5。