Crinnolines can serve as unique and versatile class of heterocycles especially in fields related to synthetic and pharmaceutical chemistry owing to their potent biological activities. They possess diversity of pharmaceutical activities as anticancer, antibacterial, anti-inflammatory, anti-allergic as well as anti-hypertensive activities. Since the first synthesis of cinnoline by Richter (1883) numerous protocols for their synthesis have been developed utilizing arenediazonium salts, aryl hydrazines and arylhydhydrazones precursors. Recently metal catalyzed C-C and C-N bond formation reactions have emerged as efficient tools for synthesis of cinnoline derivatives. This review aims to focus on the recent synthetic routes used for the synthesis of cinnoline derivatives. An effort has been carried out to provide an overview of practical methods for preparing cinnolines. Furthermore the reaction mechanisms have been described in brief.

亚麻籽油因其强大的生物活性而可作为独特的多用途杂环类，尤其是在与合成和药物化学相关的领域中。它们具有多种药物活性，例如抗癌，抗菌，抗炎，抗过敏以及抗高血压活性。自Richter（1883）首次合成肉桂酸以来，已经开发了许多使用壬二唑鎓盐，芳基肼和芳基氢azo酮前体的合成方案。近来，金属催化的CC和CN键形成反应已经成为合成肉桂酸衍生物的有效工具。这篇综述的目的是集中在用于合成肉桂酸衍生物的最新合成途径上。已经进行了努力以提供用于制备肉桂醛的实用方法的概述。此外，已经简要描述了反应机理。