Bright and Stable NIR‐II J‐Aggregated AIE Dibodipy‐Based Fluorescent Probe for Dynamic In Vivo Bioimaging,Angewandte Chemie International Edition

当前位置： X-MOL 学术 › Angew. Chem. Int. Ed. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Bright and Stable NIR‐II J‐Aggregated AIE Dibodipy‐Based Fluorescent Probe for Dynamic In Vivo Bioimaging
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2020-09-23 , DOI: 10.1002/anie.202012427
Qisong Zhang ₁ , Peng Yu ₁ , Yong Fan ₁ , Caixia Sun ₁ , Haisheng He ₁ , Xuan Liu ₁ , Lingfei Lu ₁ , Mengyao Zhao ₁ , Hongxin Zhang ₁ , Fan Zhang ₁

Affiliation

Organic dyes emitting in the second near‐infrared (NIR‐II, 900–1700 nm) window, with high molar extinction coefficients (MEC) and quantum yields (QY) in aqueous, are essential for in vivo bioimaging and biosensing. In this work, we developed a dibodipy‐based aggregation‐induced emission (AIE) fluorescent probe, THPP, to meet this aim. THPP exhibits a high MEC and has intensified absorption and emission in J‐aggregated state, which significantly enhance the fluorescence intensity (≈55 folds) and extend the maximal absorption/emission wavelengths to 970/1010 nm in NIR‐II region. Based on the bright THPP, imaging with a high frame rate (34 frames per second) at a deep “valid penetration depth” up to 6 mm can be achieved. This enabled simultaneous and dynamic imaging of vasculatures and deep tissues. Besides, we succeeded in monitoring the respiratory rate of acute‐lung‐injury mice and tracing the collateral circulation process with a high frame rate.

中文翻译：

明亮，稳定的NIR-II J聚集的基于AIE Dibodipy的荧光探针可用于动态体内生物成像

在第二近红外（NIR-II，900-1700 nm）窗口中发射的有机染料具有很高的摩尔消光系数（MEC）和水溶液中的量子产率（QY），对于体内生物成像和生物传感至关重要。在这项工作中，我们开发了一种基于双链的聚集诱导发射（AIE）荧光探针THPP来实现此目标。THPP表现出较高的MEC并在J聚集状态下增强了吸收和发射，这显着增强了荧光强度（约55倍），并在NIR-II区将最大吸收/发射波长扩展到970/1010 nm。基于明亮的THPP，可以实现高达6毫米的“有效穿透深度”的高帧速率（每秒34帧）的成像。这样就可以对血管和深层组织同时进行动态成像。此外，我们成功地监测了急性肺损伤小鼠的呼吸频率，并以高帧频追踪了侧支循环过程。

更新日期：2020-09-23

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南