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Solar Freckles: Long-Term Photochromic Tattoos for Intradermal Ultraviolet Radiometry.
ACS Nano ( IF 15.8 ) Pub Date : 2020-09-22 , DOI: 10.1021/acsnano.0c05723
Jesse L Butterfield 1 , Sean P Keyser 1 , Karan V Dikshit 2 , Hyejin Kwon 1 , Maranke I Koster 3 , Carson J Bruns 1, 4
Affiliation  

While tattooable nanotechnology for in-skin sensing and communication has been a popular concept in science fiction since the 1990s, the first tattooable intradermal nanosensors have only emerged in the past few years, and none have been demonstrated in human skin. We developed a photochromic tattoo that serves as an intradermal ultraviolet (UV) radiometer that provides naked-eye feedback about UV exposure in real time. These small tattoos, or “solar freckles”, comprise dermally implanted colorimetric UV sensors in the form of nanoencapsulated leuco dyes that become more blue in color with increasing UV irradiance. We demonstrate the tattoos’ functionality for both quantitative and naked-eye UV sensing in porcine skin ex vivo, as well as in human skin in vivo. Solar freckles offer an alternative and complementary approach to self-monitoring UV exposure for the sake of skin cancer prevention. Activated solar freckles provide a visual reminder to protect the skin, and their color disappears rapidly upon removal of UV exposure or application of topical sunscreen. The sensors are implanted in a minimally invasive procedure that lasts only a few seconds, yet remain functional for months to years. These semipermanent tattoos provide an early proof-of-concept for long-term intradermal sensing nanomaterials that provide users with biomedically relevant information in the form of an observable color change.

中文翻译:

太阳雀斑:用于皮内紫外线辐射的长期光致变色纹身。

自1990年代以来,用于皮肤感测和通信的可纹身的纳米技术一直是科幻小说中的流行概念,但最早的可纹身的皮内纳米传感器才出现在过去的几年中,并且在人类皮肤中尚未得到证实。我们开发了一种光致变色纹身,可以用作皮内紫外线(UV)辐射计,可实时提供有关紫外线暴露的肉眼反馈。这些小纹身或“太阳雀斑”包括以纳米封装的无色染料形式植入皮肤的比色UV传感器,随着紫外线辐射的增加,其颜色会变蓝。我们展示了纹身在猪皮肤离体以及人体皮肤对定量和肉眼紫外线感应的功能。为了预防皮肤癌,太阳雀斑为紫外线自我监测提供了另一种补充方法。活化的太阳雀斑可提供视觉提醒,保护皮肤,在去除紫外线或使用局部防晒霜后,其颜色会迅速消失。传感器以微创的方式植入,仅需几秒钟,但仍可正常工作数月至数年。这些半永久性纹身为长期皮内传感纳米材料提供了一种早期的概念验证,可以以可观察到的颜色变化的形式向用户提供生物医学相关的信息。
更新日期:2020-10-28
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