High Fidelity Bidirectional Neural Interfacing with Carbon Fiber Microelectrodes Coated with Boron‐Doped Carbon Nanowalls: An Acute Study,Advanced Functional Materials

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High Fidelity Bidirectional Neural Interfacing with Carbon Fiber Microelectrodes Coated with Boron‐Doped Carbon Nanowalls: An Acute Study
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2020-09-22 , DOI: 10.1002/adfm.202006101
Maryam A. Hejazi ₁ , Wei Tong _{1,

2,

3} , Alastair Stacey _{1,

4} , Shi H. Sun ₂ , Molis Yunzab ₂ , Ali Almasi ₂ , Young Jun Jung _{2,

3} , Hamish Meffin _{2,

3} , Kate Fox _{5,

6} , Khatereh Edalati ₁ , Athavan Nadarajah ₁ , Steven Prawer ₁ , Michael R. Ibbotson _{2,

3} , David. J Garrett _{1,

5}

Affiliation

Implantable electrodes that can communicate with a small, selective group of neurons via both neural stimulation and recording are critical for the development of advanced neuroprosthetic devices. Microfiber electrodes with neuron‐scale cross‐sections have the potential to improve the spatial resolution for both stimulation and recording, while minimizing the chronic inflammation response after implantation. In this work, glass insulated microfiber electrodes are fabricated by coating carbon fibers with boron‐doped carbon nanowalls. The coating significantly improves the electrochemical properties of carbon fibers, leading to a charge injection capacity of 7.82 ± 0.35 mC cm⁻², while retaining good flexibility, stability and biocompatibility. When used for neural interfacing, the coated microelectrodes successfully elicit localized stimulation responses in explanted retina, and are also able to detect signals from single neurons, in vivo with a signal‐to‐noise ratio as high as 6.7 in an acute study. This is the first report of using carbon nanowall coated carbon fibers for neural interfacing.

中文翻译：

高保真双向神经接口与掺硼碳纳米壁的碳纤维微电极的连接：一项急性研究

可植入的电极可以通过神经刺激和记录与少量的选择性神经元进行通讯，对于开发先进的神经修复设备至关重要。具有神经元尺度横截面的超细纤维电极有可能提高刺激和记录的空间分辨率，同时最大程度地降低植入后的慢性炎症反应。在这项工作中，玻璃绝缘超细纤维电极是通过用掺杂硼的碳纳米壁涂覆碳纤维而制成的。该涂层显着改善了碳纤维的电化学性能，导致电荷注入容量为7.82±0.35 mC cm ^-2，同时保持良好的柔韧性，稳定性和生物相容性。当用于神经接口时，在一项急性研究中，包覆的微电极可以成功地在植入的视网膜中引发局部刺激反应，并且还能够在体内检测出单个神经元的信号，信噪比高达6.7。这是使用碳纳米壁涂层碳纤维进行神经接口的第一份报告。

更新日期：2020-09-22

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