Kaempferol-3-O-β-d-glucuronide (K3G) having various pharmacological effects was explored for its anti-inflammatory effect in LPS induced RAW 264.7 cells and mice model. K3G significantly inhibited various pro-inflammatory mediators like IL-1β, NO, PGE2, and LTB4. It upregulated the secretion of anti-inflammatory cytokine IL-10. K3G is found to reduce inflammation when studied for parameters like phagocytic index, carrageenan induced paw edema in mice and organ weight. It reduced inflammation in a dose dependent manner both in-vitro and in-vivo. Further molecular insights into the study reveal that K3G blocks the phosphorylation of NF-kB which is key regulator of inflammation, thereby exhibiting anti-inflammatory potential. Hence, this study permits further investigation to develop K3G as anti-inflammatory drug.

探索了具有多种药理作用的山竹酚-3-O-β- d-葡萄糖醛酸苷（K3G）在LPS诱导的RAW 264.7细胞和小鼠模型中的抗炎作用。K3G显着抑制各种促炎介质，如IL-1β，NO，PGE2和LTB4。它上调了抗炎细胞因子IL-10的分泌。当研究吞噬指数，角叉菜胶诱发的小鼠爪水肿和器官重量等参数时，发现K3G可减轻炎症。它降低以剂量依赖的方式既炎症体外和在体内。对该研究的进一步分子了解表明，K3G阻断了炎症关键调节因子NF-kB的磷酸化，从而具有抗发炎的潜力。因此，该研究允许进一步研究开发K3G作为抗炎药。