The crown ether size and stereochemistry affect the self-assembly, hydrogelation, and cellular interactions of crown ether/peptide conjugates,Journal of Materials Chemistry B

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The crown ether size and stereochemistry affect the self-assembly, hydrogelation, and cellular interactions of crown ether/peptide conjugates
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2020-09-21 , DOI: 10.1039/d0tb01913e
Abdelreheem Abdelfatah Saddik _{1,

2,

3} , Mohiuddin Mohammed _{1,

2,

3} , Hsin-Chieh Lin _{1,

2,

3}

Affiliation

The discovery of crown ethers and their unique interactions with ions make them play a key role in supramolecular chemistry. In this study, we have developed a new type of amphiphilic crown ether (DB18C6, DB24C8)-conjugated phenylalanine dipeptides for the gelation of water at physiological pH. We report here for the first time that the size of the crown ether controlled the morphology of the self-assembled nanostructures of the hydrogels, as well as their interactions with human mesenchymal stem cells (hMSCs; 3A6-RFP) and mouse fibroblasts (L929). For example, relative to its D-form and other crown sizes, DB18C6^LF^LF exhibited greater cell adhesion and was nontoxic towards hMSCs after culturing for 72 h. We hypothesize that the steric effect of the crown ether moiety in the assemblies has substantial influences on the morphology of the nanostructures and the cell–material response. Such distinct cell responses should be beneficial for the development of supramolecular biomaterials.

中文翻译：

冠醚的大小和立体化学会影响冠醚/肽共轭物的自组装，水凝胶化和细胞相互作用

冠醚及其与离子的独特相互作用的发现使它们在超分子化学中起着关键作用。在这项研究中，我们开发了一种新型的两亲冠醚（DB18C6，DB24C8）偶联的苯丙氨酸二肽，用于在生理pH值下凝胶化水。我们在这里首次报道冠醚的大小控制着水凝胶自组装纳米结构的形态，以及它们与人间充质干细胞（hMSCs; 3A6-RFP）和小鼠成纤维细胞（L929）的相互作用。。例如，相对于D形和其他表冠尺寸，DB18C6 ^L F ^L培养72小时后，F表现出更大的细胞粘附性并且对hMSC无毒。我们假设冠状醚部分在装配体中的空间效应对纳米结构的形态和细胞-材料反应具有重大影响。此类独特的细胞反应应有助于超分子生物材料的开发。

更新日期：2020-10-13

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