Magnoflorine is an important quaternary aporphine alkaloid that is isolated from some commonly used herbal medicines (e.g., Sinomenium acutum (Thunb.) Rehder & E.H.Wilson and Coptis chinensis Franch.). In recent years, magnoflorine has received increasing attention due to its multiple pharmacological activities. This review provides the first comprehensive summary of the plant sources, pharmacological effects, toxicity, and pharmacokinetic characteristics of magnoflorine. The results indicated that magnoflorine possesses a wide spectrum of pharmacological properties, including anti-diabetic, anti-inflammatory, neuropsychopharmacological, immunomodulatory, hypotensive, antioxidant, and antifungal activities. Pharmacokinetic studies have shown that magnoflorine has low bioavailability and high absorption and elimination rates. However, the other compounds (e.g., berberine) present in herbal medicines could reduce the absorption and removal rates of magnoflorine and increase its bioavailability. Moreover, toxicity studies have suggested that magnoflorine is non-toxic to most cells. However, long-term and high-dose toxicity testing in animals is still lacking. In view of good pharmacological activities, magnoflorine is expected to be a potential drug candidate for the treatment of diabetes, depression, or Alzheimer's disease. However, further studies are needed to elucidate its molecular mechanisms and targets, clarify its toxicity, and improve its oral bioavailability.

Magnoflorine是一种重要的季铵盐类生物碱，它是从一些常用草药（例如，Amenumium acutum（Thunb。）Rehder＆EHWilson和Coptis chinensisFranch。）。近年来，由于其多种药理活性，厚朴素已受到越来越多的关注。这篇综述提供了厚朴素的植物来源，药理作用，毒性和药代动力学特征的第一份综合摘要。结果表明，厚朴素具有广泛的药理特性，包括抗糖尿病，抗炎，神经心理药理，免疫调节，降压，抗氧化剂和抗真菌活性。药代动力学研究表明，厚朴素具有较低的生物利用度以及较高的吸收和消除率。但是，其他化合物（例如，小碱）可以降低木兰花素的吸收和去除率，并提高其生物利用度。此外，毒性研究表明，厚朴素对大多数细胞无毒。但是，仍然缺乏对动物的长期和大剂量毒性试验。考虑到良好的药理活性，厚朴花碱有望成为治疗糖尿病，抑郁症或阿尔茨海默氏病的潜在药物。但是，需要进一步研究以阐明其分子机制和靶标，阐明其毒性并提高其口服生物利用度。