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Electrosynthesis of 2-(1,3,4-Oxadiazol-2-yl)aniline Derivatives with Isatins as Amino-attached C1 Sources.
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2020-09-21 , DOI: 10.1021/acs.joc.0c01700
Peng Qian 1 , Zhenghong Zhou 2 , Li Wang 1 , Zhicheng Wang 1 , Zhongwei Wang 1 , Zhenlei Zhang 1 , Liangquan Sheng 1
Affiliation  

An intramolecular decarboxylative coupling reaction for the construction of 2-(1,3,4-oxadiazol-2-yl)aniline derivatives was developed from readily available isatins and hydrazides by virtue of electrochemistry. In this reaction, isatins were employed as amino-attached C1 sources, providing a variety of 2-(1,3,4-oxadiazol-2-yl)aniline derivatives with moderate to good yields.

中文翻译:

以Isatins为氨基连接的C1源电合成2-(1,3,4-Oxadiazol-2-yl)苯胺衍生物。

通过电化学从易得的靛红和酰肼中开发出用于构建2-(1,3,4-恶二唑-2-基)苯胺衍生物的分子内脱羧偶联反应。在该反应中靛红被用作氨基连接的C1来源,以中等至良好的产率提供了各种2-(1,3,4-恶二唑-2-基)苯胺衍生物
更新日期:2020-10-17
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