Nerve endings and terminal Schwann cells (TSCs) specifically and densely surround hair follicle at isthmus area, forming a neuromuscular‐junction‐like structure called lanceolate complex. The interplay between neuronal components and epidermis in this specialized structure enables hair to properly sense complex stimuli from environments. However, how nerves precisely attach to and innervate this specific region during development remains to be elucidated. Here, we demonstrate that SEMA3C, a secreted protein member of semaphorin family responsible for axonal guidance, is localized right below sebaceous gland and in close approximation with nerve endings and TSCs processes all through the entire hair cycle. SEMA3C protein is deposited outside of epithelial cells and its expression is independent on the presence of nerve endings/TSCs. SEMA3C is also found in portions of dermal papilla at growth phase. The tight spatial association of SEMA3C with lanceolate complex suggests that it might play roles in establishment and/or maintenance of the lanceolate complex in hair follicle.

中文翻译：

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SEMA3C与毛囊峡部神经末梢/终末雪旺细胞的空间关联

神经末梢和终末雪旺氏细胞（TSCs）在峡部区域特异性且密集地包围毛囊，形成称为披针形复合体的神经肌肉接头样结构。这种特殊结构中神经元成分和表皮之间的相互作用使头发能够正确感知来自环境的复杂刺激。然而，神经在发育过程中如何精确地附着并支配这个特定区域仍有待阐明。在这里，我们证明 SEMA3C 是负责轴突引导的信号素家族的分泌蛋白成员，位于皮脂腺正下方，在整个头发周期中与神经末梢和 TSC 过程非常接近。SEMA3C 蛋白沉积在上皮细胞外，其表达与神经末梢/TSC 的存在无关。在生长期的真皮乳头部分中也发现了 SEMA3C。SEMA3C 与披针形复合体的紧密空间关联表明它可能在毛囊中披针形复合体的建立和/或维持中发挥作用。